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Author Topic: Pre-pubescent girl with anaphylaxis (no known allergies)  (Read 918 times)

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Offline TBrown

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Pre-pubescent girl with anaphylaxis (no known allergies)
« on: February 06, 2016, 06:52:11 PM »
My ten year old daughter has been having anaphylaxis with no known allergies. First reaction was on January 3, second three days ago, on February 3.

Because we have had no signs in the past of sensitivities and because of the irony of the dates of the reactions, I'm wondering if it is possible that her estrogen level may have something to do with her new sensitivity/allergy.

Has anyone ever heard of this possibility?

Offline CMdeux

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #1 on: February 06, 2016, 09:48:16 PM »
No-- and I've looked, actually, because my daughter had cyclic reactions and was FAR more volatile for a while after she was mid-way through puberty.

Hormone levels may make women more likely to anaphylax, or do to so more severely, during some points during a menstrual cycle, but as far as I ever could find literature for it, there's nothing to suggest that they make anaphylaxis itself HAPPEN in the absence of another trigger.

Of course, new allergies during adolescence are a known thing. 

So-called idiopathic anaphylaxis is horrible.  I hope that you can figure out what the underlying trigger has been. 
Resistance isn't futile.  It's voltage divided by current. 

Western U.S.

Offline GoingNuts

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #2 on: February 07, 2016, 07:26:16 AM »
^^ What CM said.  I was also going to suggest idiopathic anaphylaxis, which I hope is not the case.

Has she been seen by a board certified allergist?  Can you think of any commonalities between episodes?
"Speak out against the madness" - David Crosby
N.E. US

Offline TBrown

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #3 on: February 07, 2016, 08:06:09 AM »
We are in northern Ontario, Canada and are awaiting an appointment with a specialist.

There have been no correlation between the two episodes and each time nothing new was introduced. The most recent episode actually happened in her sleep. I am so thankful she woke up and realized what was happening.


Offline GoingNuts

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #4 on: February 07, 2016, 08:54:09 AM »
How scary for you.  I hope you can get some answers soon.  :grouphug:
"Speak out against the madness" - David Crosby
N.E. US

Offline eragon

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #5 on: February 07, 2016, 11:36:36 AM »
my son has idiopathic angioedema which started during  at 13/14yr. wakes up with swollen, face, lips, eyes lids , tight throat.  Recently at 19 had slightly swollen tongue.

He has it controlled with 3 antihistamines when really bad, and should be on 2 types a day at least. It peaks during stressful times and illness.

I know this isn't what your daughter has, but this stuff does seem to happen to allergic teens. my non food allergic daughter started with her milk allergy at 13, and thankfully its burning out at 17 now (long story). 

It took 6 months to get this condition confirmed and sorted. It's difficult, and scary to deal with and watch. I hope things get better soon for your daughter.   
Its OK to have dreams:one day my kids will be legal adults & have the skills to pick up a bath towel.

Offline lakeswimr

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #6 on: February 08, 2016, 06:49:50 AM »
It could be idiopathic but it would also be a new food allergy. People can develop food allergies at any time.  Symptoms usually start within minutes to up 2 hours of ingestion.  This happens 99.9% of the time.  99% of the time symptoms start within minutes to 30 or 45 minutes of eating the food.  If the symptoms are not treated with epinepherine, then they can continue and be protracted.  So, the reaction in her sleep could be a reaction that started earlier and was more minor at that time.  Did she feel fine until then? 

People can have ana to heat and cold and to exercise.  You might think of those things.

What were her symptoms?  Do you have epi pens now?  If not, call the pediatrician and ask for them today.

I do think it is possible that hormone shifts could influence the development of or outgrowth of food allergies but that might easily be totally unrelated. 

I would keep a food and symptom journal where you write down everything she eats and all symptoms she has and the time of each.

What did she eat before both reactions?

Offline TBrown

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #7 on: March 11, 2016, 07:02:21 PM »
Update: My daughter underwent allergy testing of the 56 most common allergens (ie: peanuts, dust, cat, dog...) and every single one was negative.

Since that test date, she has had another anaphylactic reaction, three in total since January 3.  Each of the reactions is an average of 33 days apart.

Have anyone heard of an allergy to ones own progesterone? Could it be possible that a girl who has not yet started menstruating, but has certainly started puberty, would have increased levels of progesterone that could cause anaphylaxis?

We have an appointment for more extensive allergy testing in June.

I appreciate all your comments.

Offline rebekahc

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #8 on: March 11, 2016, 07:29:08 PM »
I'm leaning away from allergy at this point since negative tests are pretty accurate. What about a mast cell disorder?  If you google mast cell disorder hormones, it appears there is a strong correlation between estrogen (and maybe progesterone) and triggering of mast cells.

So sorry you still don't have answers - how scary and frustrating!  :grouphug:
TX - USA
DS - peanut, tree nut, milk, eggs, corn, soy, several meds, many environmentals. Finally back on Xolair!
DD - mystery anaphylaxis, shellfish.
DH - banana/avocado, aspirin.  Asthma.
Me - peanut, tree nut, shellfish, banana/avocado/latex,  some meds.

Offline CMdeux

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #9 on: March 11, 2016, 11:58:35 PM »
That really seems to me to be more likely than allergy-- and ohhhh, how I wish that it WAS an allergy for your sakes.   :-[
Resistance isn't futile.  It's voltage divided by current. 

Western U.S.

Offline TBrown

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Re: Pre-pubescent girl with anaphylaxis (no known allergies)
« Reply #10 on: March 12, 2016, 08:09:24 AM »
What about catamenial anaphylaxis?

She is approaching menarche. Could she be allergic to her own progesterone?