nameless, as far as I've been able to tell, there isn't one.
Compounding work would be done with diphenhydramine in powdered or liquid concentrates for use
in gels, creams, saline for IV use, and oral elixirs.
COULD either concentrate be used to compound a fast-melting single-dose packet for oral administration? It's doubtful to me personally, given what I know of formulations work.
Unfortunately, this is a pretty specialized delivery mode, and it's one that pretty much has to be done industrially.
Read more about this technology
here and
here. Also see
here for a discussion of the materials chemistry behind the manufacturing problems involved. Thinstrips are an example of an "oral film" rather than a FDT. A discussion of the manufacturing of oral films is
here. (That last one is clearly translated into English, but the information, while a little on the over-enthusiastic side, is mostly accurate).
Quick-dissolving TABLETS? That's do-able. Oral films, not so much.
Adding liquid
to another fast-melting product will cause it to disintegrate (so using a glucose tablet and dropping diphenhydramine ONTO it won't work well), and drying out a hygroscopic material is.... well, difficult outside of a laboratory setting.
Using powder would require a binder of some sort that is safe for oral use, can be air-dried, and is stable enough to be sealed. The very properties of this kind of delivery system make two of those competing and contradictory in practical terms-- anything hygroscopic enough to work as an orally-dissolving strip is too hygroscopic to be readily handled in a standard compounding pharmacy at normal humidities. You'd need to make and seal them in a glove box under nitrogen, probably, if they were to be shelf-stable for months at a time. <sigh>
Chewables or rapidly dissovling tablets can be compounded with simple dry-compression methods-- but what would be the point, since those
are still commercially available, YK?
Theoretically, you COULD use topical diphenhydramine products, which are readily absorbed systemically. The problem is that dosing is so darned unpredictable because it depends on both volume delivered and on surface area covered as well as rate of absorption through the skin. Darnit.
We, too, were HUGE fans of these strips. You could actually stuff a couple inside the carry-tubes with an epipen, and as brownie noted, put a couple in a wallet, for heaven's sakes! You certainly can't do that with fast melts, nevermind with a premeasured spoon.
The other nice thing about these was that it was possible to split the dose up by tearing the strips into halves or thirds.
