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cow's milk mediated EoE (CMME)
The authors’ findings suggest that a majority of patients with CMME could tolerate baked milk products without recurrence of EoE.
The researchers performed a retrospective analysis of all children seen at CHOP for EoE between 2000 and 2012, a total of 1,375 patients. Of that number, 425 could be shown to have a definite food causing their condition—most commonly milk, egg, soy and wheat. Within that subgroup, 17 patients had developed EoE to a food after having outgrown IgE-mediated allergy to that specific food.
Approximately half of the patients treated with corticosteroids reported symptomatic improvement while over three-quarters of patients reported an improvement on allergy avoidance dietary therapy. At a median follow-up of 31.1 (IQR=81.8-13.4) months, 16 (17%) patients had no change in symptoms from diagnosis, 53 (56%) patients continued to experience symptoms but at a decreased severity, and 17 (18%) experienced a complete resolution of symptoms. Eight (9%) of patients were lost to follow up.
The most commonly reported symptoms were food impaction (67%), dysphagia (53%), abdominal pain (40%), vomits (37%) and heartburn (37%); the first 2 were significantly more frequent in adults and adolescents. Children's (≤12 years) main complaint was vomits (60%) and failure to thrive occurred in 2 cases. Most had personal history of allergic disease (87%) and aeroallergens sensitization (71%).
Rationale: Eosinophilic esophagitis (EoE) can be treated with various combinations of a proton pump inhibitor (PPI), topical steroid (TS), and elimination diet (D). This study assessed which treatments patients were using and sought to determine patient/caregiver ratings of EoE symptoms, response to treatment, and tolerability of therapy.
Use of a topical steroid was associated with significantly higher treatment response ratings and very few side effects.
Researchers at the Cincinnati Children’s Hospital have developed a ground breaking diagnostic test for eosinophilic esophagitis, or EoE.
It also differentiated between those whose EoE was in remission and those who didn’t have EoE at all.
The test uses a method known as gene expression profiling
This position paper of the Eosinophilic Esophagitis Working Group (see Appendix) and the Gastroenterology Committee of ESPGHAN aims at providing practical guidelines for the management of children and adolescents with EoE, based on available evidence where possible. If sufficient evidence is lacking, our recommendations are based on expert opinion and personal practice.
Esophageal eosinophilia and eosinophilic esophagitis (EoE) are increasingly recognized and prevalent conditions, which now represent common clinical problems encountered by gastroenterologists, pathologists, and allergists.
In this evidence-based review, recommendations developed by adult and pediatric gastroenterologists are provided for the evaluation and management of these patients.
This paper reviews the evidence for all types of dietary therapy in eosinophilic esophagitis.
“In a nutshell, we have used cutting edge genomic analysis of patient DNA as well as gene and protein analysis to explain why people develop EoE,” Rothenberg explained. “This is a major breakthrough for this condition and gives us a new way to develop therapeutic strategies by modifying the expression of calpain14 and its activity.
The allergy world was abuzz this past week that a major research breakthrough for Eosinophilic Esophagitis (EoE) was published in Nature Genetics (1), spear-headed by Dr. Marc Rothenberg’s lab at Cincinnati Children’s Hospital. For anyone dealing with this devastating allergic disorder, the news was welcome, but what does it all mean?
Many factors contribute to the complex interplay of nature (DNA) and nurture (environmental effects on DNA expression) in both health and disease, and this is true for EoE and other allergic disorders.
CAPN14 is clearly one piece of the complex machinery that scientists are trying to reverse engineer.
But Hunter’s doctors at the Mayo Clinic had another idea: a simple sponge on a string developed in the United Kingdom.
When a doctor pulls it back up, it scrapes the lining of the esophagus. It takes just five minutes and a pilot study found it was just as effective as an endoscopy.
A potential marker of disease activity for a severe and often painful food allergic disease called eosinophilic esophagitis (EoE) has been discovered by researchers, possibly sparing children with EoE the discomfort and risk of endoscopic procedures to assess whether their disease is active.
Published May 16 in the Journal of Allergy and Clinical Immunology, researchers at the Cincinnati Center for Eosinophilic Disorders (CCED) at Cincinnati Children's Hospital Medical Center led the study.
A five-year, $6.25 million NIH grant will establish the Consortium of Eosinophilic Gastrointestinal Disease Researchers, or CEGIR.
the Hargers visited the Gerson Institute in San Diego
The alternative dietary Gerson Therapy was developed by Max Gerson (1881-1959), a German-born American physician who originally came up with the idea as a cure for his debilitating migraines. He further claimed it was a cure for cancer and most chronic, degenerative diseases.
Brian Clement’s clinic has nothing to do with Ongwehowe Onongwatri:yo (indigenous medicines) and everything to do with good, old-fashioned European-American quackery focused mainly on wheatgrass, raw vegan diet, and “detoxification.”
there is still another aboriginal girl with lymphoblastic leukemia who has abandoned chemotherapy, with the blessing of her tribal chiefs and family, in favor of the quackery peddled by a Yankee in Florida. We don’t know her name due to privacy concerns enforced during her court case but we do have an update about her condition to juxtapose with the death of Makayla Sault.