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Author Topic: Epinephrine Nasal Spray in Phase 1 of Trial  (Read 1212 times)

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Offline Macabre

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Epinephrine Nasal Spray in Phase 1 of Trial
« on: December 11, 2017, 01:23:53 PM »
https://snacksafely.com/2017/12/phase-i-trial-of-epinephrine-nasal-spray-for-anaphylaxis-begins/

Quote
INSYS Therapeutics announced Thursday that it has begun a proof-of-concept study of two formulations of epinephrine nasal spray for the treatment of anaphylaxis with the enrollment of the first patient.

This Phase I clinical trial is designed to establish whether intranasal administration of epinephrine is bioequivalent to the standard method of delivering the drug via intramuscular injection. . . . .


Me: Sesame, shellfish, chamomile, sage
DS: Peanuts

Offline PurpleCat

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Re: Epinephrine Nasal Spray in Phase 1 of Trial
« Reply #1 on: December 11, 2017, 04:54:03 PM »
Exciting!

Offline spacecanada

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Re: Epinephrine Nasal Spray in Phase 1 of Trial
« Reply #2 on: December 11, 2017, 05:25:08 PM »
I have to wonder how well a nasal spray would work with nasal symptoms being part of a reaction.  Think of a really snotty reaction; I don't think a spray could be effective then, or when you have congestion from other conditions such as viruses.  It will be interesting to see how the trial considers those factors. (They are spraying allergens in the nose and seeing how it affects the epinephrine.)

Sounds like an interesting experiment, for sure. 
« Last Edit: December 11, 2017, 05:32:17 PM by spacecanada »
anaphylaxis to tree nuts, peanuts, potato, wheat, and sorghum

Offline spacecanada

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Re: Epinephrine Nasal Spray in Phase 1 of Trial
« Reply #3 on: November 10, 2019, 05:06:21 PM »
My question has been answered... well, sort of.

https://www.prnewswire.com/news-releases/bryn-pharma-research-on-epinephrine-nasal-spray-presented-at-the-american-college-of-allergy-asthma-and-immunology-annual-meeting-300955162.html

Apparently congestion makes the nasal epinephrine more effective?  Someone please explain this to me better than the article above.  What about a gushing runny nose?  or sneezing? 

I'm not sure I would rely on it as a first measure, as I think IM may still be needed in some cases.  Still, more options are a good thing.  Great, even, if they work in a practical setting.
anaphylaxis to tree nuts, peanuts, potato, wheat, and sorghum