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Specific Food Allergies > Seed Allergy

Sesame Research (links clearinghouse thread)

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"Demographic Predictors of Peanut, Tree Nut, Fish, Shellfish, and Sesame Allergy in Canada"

M. Ben-Shoshan,1 D.W. Harrington,2 L. Soller,3 J. Fragapane,3 L. Joseph,3, 4
Y. St. Pierre,3 S. B. Godefroy,5 S. J. Elliott,6 and A. E. Clarke3, 7

"Sesame Allergy: Role of Specific IgE and Skin Prick Testing in Predicting Food Challenge Results"

Perdita Permaul, MD,ab Lisa M. Stutius, MD,ab William J. Sheehan, MD,ab Pitud Rangsithienchai, MD, MA,ac Jolan E. Walter, MD, PhD,ab Frank J. Twarog, MD, PhD,ab Michael C. Young, MD,ab Jordan E. Scott, MD,ab Lynda C. Schneider, MD,ab and Wanda Phipatanakul, MD, MSab

--- Quote ---Although our study is limited by a small sample of cases, there is an inclination for predicting the outcome of a sesame food challenge with SPT based on our results

--- End quote ---

--- Quote ---Notably, 29% of sesame allergic patients had a sesame-specific IgE < 0.35 kUA/L. This is in contrast to the findings of Zavalkoff et al. who reported a cut-off < 0.35 kUA/L as being useful in excluding a diagnosis of sesame allergy.

--- End quote ---

This is from 2003 ... I'm not sure if there has been more research since then.  Not a big sample size for sesame.

"Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenges."

--- Quote ---Data from 125 positive oral challenges to egg, 103 to peanut, 59 to milk and 12 to sesame seeds were analysed. Haemodynamic modifications were observed in 2%, 3%, 1.7%, and 8% of the oral challenges (OCs) to egg, peanut, milk and sesame, respectively. Respiratory symptoms were observed in 12%, 20%, 10% and 42% of egg, peanut milk and sesame allergies, respectively. A cumulative reactive dose inferior or equal to 65 mg of solid food or 0.8 mL of milk characterized 16%, 18%, 5% and 8% of egg, peanut, milk and sesame allergies, respectively. 0.8% of egg allergies, 3.9% of peanut allergies, and 1.7% of milk allergies reacted to 10 mg or less of solid food or to 0.1 mL for milk. The lowest reactive threshold has been observed at less than 2 mg of egg; 5 mg of peanut, 0.1 mL of milk and 30 mg of sesame seed. Ten out of 29 OC with peanut oil, two out of two OC with soy oil and three out of six OC with sunflower oil were positive. Five out six OC with sesame oil were positive: 1 and 5 mL induced an anaphylactic shock.

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"Sesame allergy: a growing food allergy of global proportions?"

--- Quote ---Evidence was found for increased reporting of sesame allergy during the past 5 decades, with reports mostly from developed countries. Clinically, most sesame allergy was presented in at least 2 major forms: (1) immediate hypersensitivity, often expressed as systemic anaphylaxis, associated with positive skin prick test and/or IgE antibody test results to sesame proteins with some cross-reactivity with other foods, and (2) delayed hypersensitivity to lignin-like compounds in sesame oil clinically expressed as contact allergic dermatitis. There were a few cases of immediate hypersensitivity to sesame with negative skin prick test and/or IgE antibody test results that were confirmed by oral challenge tests.

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Is there a positive predictive value for sesame?

Sesame prevalence studies: Canada & USA


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