[Hello all,
first post here] I've read many papers where the DBPCFC is called the gold standard test to see if someone should not be diagnosed as allergic to something anymore. But I am wondering who exactly is blind in a peanut challenge.
How do you hide something like several grams of peanut flour in a small amount of food (that can be eaten in ~10 min) so that that the presence/smell of peanut and oat flour really remains blind to both researcher and subject? I think I could easily smell even 0.5g of peanut flour mixed in applesauce or yogurt a mile away. I guess they would have to mix each into about a 0.25 - 0.5 cups of Sunbutter in order to obscure peanut to me. Do they make everyone wear clothespins on their noses?
Like in the following paper [J ALLERGY CLIN IMMUNOL, VOLUME 127, NUMBER 3, VARSHNEY ET AL. (bolding mine)], the maximum single dose is 4000mg if the child makes it that far. Is it reasonable to assume that
no one can tell at any point within the challenge? (Sorry if this has been discussed before elsewhere -- if anyone sends me a link, I will be happy to follow it.)
Build-up visits. Subjects returned every 2 weeks for approximately
44 weeks for dose escalations. Doses were increased by 50% to 100% until the
75-mg dose and were then increased by 25% to 33% until the
4000-mg
maintenance dose was reached.
Maintenance phase. After reaching the maintenance dose of
peanut flour or placebo, subjects ingested the dose daily for 1 month and
then returned for the first oral food challenge (OFC) at week 48.
OFC
A double-blind, placebo-controlled food challenge was performed after 4
weeks of maintenance therapy. Before the OFC, subjects were asked to restrict
the use of antihistamines, b-agonists, theophylline, and montelukast.16 All subjects
were challenged to both peanut and oat flour in a blind manner. Challenges
were administered by a nurse or physician who was also blind to the testing materials.
The challenge consisted of peanut or oat flour given in increasing doses
every 10 to 20 minutes up to a
cumulative dose of 5000 mg protein.