Quote from: LinksEtc on March 08, 2014, 07:45:44 PMQuote from: CMdeux on March 08, 2014, 04:56:01 PM
Anaphylaxis
Notice-- epinephrine, epinephrine, epinephrine...
At about 6:48, they seem to emphasize salbutamol for breathing symptoms. They mention that if epi already given, that would help also ..... but, they don't seem to stress that epi also must be given![]()
Again at 12:05.
They define ana as more than 1 body system. What if just breathing issues?
Thoughts?
Quote from: CMdeux on March 08, 2014, 04:56:01 PM
Anaphylaxis
Notice-- epinephrine, epinephrine, epinephrine...
Quote
Respiratory compromise and cardiovascular collapse cause most fatalities (28, 34).
Quote
Increased vascular permeability during anaphylaxis can shift up to 35% of intravascular fluid to the extravascular space within 10 minutes.(35) The intrinsic compensatory response to anaphylaxis (endogenous epinephrine and other catecholamines, as well as angiotensin II, endothelin-1, etc) also influences the extent of clinical manifestations and, when adequate, may be lifesaving independent of medical intervention, which sometimes contributes to diagnostic and therapeutic confusion.
QuoteMast cell activation through FcεR1 is central to the pathogenesis of allergic diseases, including anaphylaxis, allergic rhinitis, and allergic asthma. Activation of FcεR1 by polyvalent allergen recognized by bound IgE leads to the initiation of an immediate hypersensitivity reaction, as well as a late-phase reaction. The immediate reaction is determined by pre-formed mediators and rapidly synthesized lipid mediators and results in: erythema, edema, and itching in the skin; sneezing and rhinorrhea in the upper respiratory tract; cough, bronchospasm, edema, and mucous secretion in the lower respiratory tract; nausea, vomiting, diarrhea, and cramping in the gastrointestinal tract; and hypotension. Late phase reactions are mediated by cytokines and chemokines and can occur 6–24 hours after the immediate reaction. Late phase reactions are characterized by edema and leukocytic influx and may play a role in persistent asthma.
Quote08.09.2011 at 12:47:43, CMdeux wrote:QuoteVERY important to understand something which is implied (but not directly stated) in the above--
epinephrine treats the SYMPTOMS of anaphylaxis, making them more survivable.
It doesn't "stop" or "reverse" the underlying cause of the systemic allergic cascade-- ergo, emergency medical aid is STILL AN ABSOLUTE REQUIREMENT after using epinephrine, because medical providers have additional tools for supporting a person who is experiencing anaphylaxis. (Steroids, intravenous fluids for volume depeletion, additional antihistamines and other second-messenger agonists/antagonists.)
That's kind of why I chose 'works to stop' instead of 'stops anaphylaxis'.
Do you think I should edit the title of this thread...Or is it best to leave it for simplicity's sake?