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Title: Bendaryl vs. Epi ... help!
Post by: ctmartin on March 20, 2012, 04:30:45 PM
Hi Everyone,

I have most recently been posting on the reactions page because my daughter had a severe reaction requiring epi last week.  In the aftermath, I spoke with a nurse practitioner at Duke today (my daughter's allergist, Dr. Burks, is no longer at Duke and they have yet to replace him) and asked her questions that I had hoped would make me more certain on my course of action next time.  However, the info I received was even more confusing  to me!

I have always been under the impression that benadryl does not *stop* a reaction in its tracks (only epi does) ... that it would only treat the symptoms.  Obviously, considering the fact that my daughter's reaction, untreated, progressed to anaphylaxis, the administration of the epi pen became necessary.  HOWEVER, the nurse practitioner was surprised that I had not given benadryl when I first suspected a reaction.

The reason I did not (besides the fact that we did not have benadryl in the house ... now we do), is because I wasn't completely sure a reaction was taking place and I was afraid  to administer benadryl and (1) possibly mask the symptoms, only to have them return later with a vengeance once the antihistamine wore off and (2) risk the possibility of her becoming sleepy where i couldn't monitor her sufficiently (the nurse's response to this was that surely she would wake up if she were having difficulty breathing, but the thought of that terrifies me, not to mention the trouble that might be caused if her GI symptoms reoccurred while she was sleeping and she ended up vomiting and possibly choking on it!!).

She told me that most reactions resolve with an antihistamine, and if I was worried about drowsiness I could give zyrtec instead.  Has anyone else ever heard this?  Now keep in mind, we did not know at the time what she was reacting to, so technically there was "no known ingestion."  I just think it seems giving benadryl is really risky, however, maybe I am wrong and if I had administered it before we were in emergency mode (i.e. head to toe hives, coughing and wheezing), epi might not have been needed?

Also, she told me that it is time to get Epi, rather than Epi Jr., but the packaging says 65 pounds for Epi, and my daughter is only 44 (she is at the borderline of when Duke suggests changing over).  When I asked the nurse if there would be a problem administering too much epi, she said she didn't "expect" there would be.  Didn't sound too sure to me!

Any info, comments, anecdotes greatly appreciated.  I am going to try to research these issues with different allergists and see what the consensus agrees on (if there could possibly be a consensus on these types of things!)  Thanks!!
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on March 20, 2012, 06:58:39 PM
I suspect that you may be as knowlegeable as the pros on this one, since this is largely a matter of pharmacology rather than established medical practice.

KWIM?

Yes, diphenhydramine is sedating.  Second gen antihistamines aren't, and some (fexofenadine and cetirizine in particular) are great at treating cutaneous symptoms in particular... BUT... they don't hit both receptor subtypes, which means that they don't put any kind of damper on GI stuff the way the sedating ones do.  Oh-- and for that reason, benadryl works a TREAT for treating nausea and other GI stuff even if it's viral.

Can it "stop" progression during a major reaction, though?

The jury is still out on this one.  The pharmacology suggests not, but there is puhhhhhlenty that isn't known about food anaphylaxis in particular.  There are a LOT of mechanstic feedback points in this particular IgE-mediated second messenger cascade.  The problem is that because some of those connection points are relatively unexplored, the answer is far from clear as to what impact receptor blockade has.  Certainly benadryl won't STOP anaphylaxis in progress.  Not once it has developed CNS features, anyway, and those are what tends to kill.  For that reason, there's NO WAY that it's a lifesaving medication.

On the other hand, is there harm in administering it promptly during a suspected/possible reaction? 

I don't think that there is.  It's what we've done for years. 

Has it "prevented" more severe reactions?  Probably not, but maybe it has prevented us from a few ER visits which were borderline (grade II to grade III without airway or cardiovascular symptoms).  <shrug>  Remember, most anaphylaxis self-resolves.  How much is "most?"  Well, nobody knows.  Obviously there is a vexing problem with collecting good data on that one.   ~)

Has it "masked" more seriouc symptoms?

Absolutely NOT.   The dosing window is so wide for benadryl that even though it has sedating effects, most of us aren't going to err significantly enough to harm our kids by giving it... and honestly, like any of us are going to let our kids out of arms reach once we've given a dose or two of benadryl, right?  So I'm not too worried about her being sleepy.  I'll be alert enough for both of us, basically.  LOL.  BTDT, spent a NUMBER of nights watching over a benadryl-dosed, sleeping child.  Even up until she was 12.

DD has been given enormous doses of Zyrtec by her allergist, but only because they kept samples on hand, and didn't for OTC benadryl. 


I know that we have a couple of threads down in RXNs about the pharmacological mechanistics of all of this.  One is about diphenhydramine and the other is about epinephrine.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on March 20, 2012, 06:59:55 PM
Oh, DD was moved from epi jr to epi at about 45 lbs, as well.  The justification was that she had severe reaction history, so was likely to need the medication in the future.  Overdosing carries a small risk of intercranial hemorrhage, but that is obviously not a great concern relative to the risks of underdosing.



(GGA.... ETC spelling.  Atrocious.)
Title: Re: Bendaryl vs. Epi ... help!
Post by: hezzier on March 20, 2012, 07:01:44 PM
I can only speak to what our allergist has advised us on our emergency action plan, but we can give benadryl for a skin only reaction and we are to epi for everything else.  From the reading I've done on this website, it sounds as if the nurse is behind the times in terms of where the general trend of treatment is going.

We switched over to the regular epi when DS was a hair below 50 lbs, basically because it was the prescription that would last for this whole school year and it seems wasteful to get Jr's for a couple months and then switch.
Title: Re: Bendaryl vs. Epi ... help!
Post by: socks on a rooster on March 20, 2012, 09:18:51 PM
I've read that some allergists are not including Benadryl in emergency plans as much because of a tendency to rely on it using the wait and see approach. We still use it at the beginning of what seems to be a reaction (single body system symptoms). The last time dd had anaphylaxis she was given Benedryl at school for an itchy mouth. She was observed for 20-30 minutes and returned to class feeling fine. By the time I picked her up from school perhaps an hour later and got home, she developed stridor (no other symptoms at all). It makes me think that without the Benedryl it would have been a faster reaction, so in a sense, it maybe did "mask" a reaction if that is what you want to call it. I'm sorry about her reaction, I'll go to the reactions board to see what happened.  :heart:
Title: Re: Bendaryl vs. Epi ... help!
Post by: Mfamom on March 20, 2012, 09:50:31 PM
The way I look at it is that it is better to be safe than sorry.  I've had 2 appts with Dr. Sicherer and have sat in on several Q & A with him.

The thing that he always says is the sooner the better with the epi pen.  He described symptoms being so unpredictable and can come down like an avalanche...once it is moving, very difficult to stop (meaning when the different systems start going into survival mode) and your chances of recovering are much higher if you are prompt with the epi pen.

So, if I "thought" my son was reacting, I would skip the benadryl and move right in with it because no harm will come from it, YK?

I did "almost" give him benadryl today because he said he was itchy all day and he had the hives on his arms from elbow down.  I was pretty sure it was an environmental thing.  He took a shower and was fine soon after. 

Also, my ds was switched to epi regular when he was 5 and initially the pharmacy wouldn't fill it.  He weighed around 50lbs

The allergist did all the math for me (I can't remember the calculation now) but the pharmacy did finally fll it.  I think it was as much his age as the weight that threw up the red flag.

Title: Re: Bendaryl vs. Epi ... help!
Post by: Macabre on March 21, 2012, 07:01:22 AM
Burks' office has a lovely form that i would suggest you have them complete and send to you right away and not wait for your appointment. It's the allergy action plan that  will no doubt look somewhat familiar to you. Burks' has a column for symptoms and then two checkbox columns for epi and Benadryl. It's very clear explaining which symptoms you epi for and which you use the other.

Both DS and I have extreme sleepiness and lethargy as reaction symptoms. I thought your concern about using benadryl was solid and brilliant, frankly. However, I guess I would have used it initially in your circumstance if i put myself in that situation. But we are used to using it and would have done that right away. And if it progressed Epid.

DS was moved to an epi regular at 45 lbs.
Title: Re: Bendaryl vs. Epi ... help!
Post by: Macabre on March 21, 2012, 06:10:10 PM
Okay--today I had a reaction. For shellfish, it affects my GI tract.  I was in a meeting. Ate something from a lunch place.  I had not taken my allegra this morning (out) but decided to take a Zantac once at work, as it's an H2 blocker (and btw--our allergist before we moved from TExas to Virginia told us to take it after anaphylaxis for a few days, as it works on different receptors). 

I first got spacey--that's what I do.  Then stomach cramps set in.  I went to CVS and bought some children's liquid benadryl. It didn't totally stop the reaction, but the second it hit my stomach, I felt better.  And this has worked for me for years (I've also had to epi for a reaction, btw).  But wow--that liquid benadryl feels sooooooooo wonderful on my stomach.

Now once DS had a reaction to some chips fried in peanut oil.  And after we gave him the Benadryl, he threw up, so I don't think it gave him benefit. But for my GI symptoms, it really feels better and works some.

BTW--my reaction has just about resolved i think  I took a second dose of benadryl about 45 minutes ago, and my small intestine is no longer hurting. 

Just posting this to give an idea of a time when it's helpful to use Benadryl.
Title: Re: Bendaryl vs. Epi ... help!
Post by: becca on March 21, 2012, 06:32:17 PM
We were always told just epi, no benadryl.  But I have given dd benadryl for hives only contact reactions.

She was changed up to a reg epi at about 45 pounds.  There is a window between 45 and 60 or 65 if I recall, that neither covers?  I would have to look that up, but recalling that from an old discussion back when I switched dd up. 
Title: Re: Bendaryl vs. Epi ... help!
Post by: Mfamom on March 21, 2012, 06:46:27 PM
Macabre, do you know what may have caused your rx today?

Title: Re: Bendaryl vs. Epi ... help!
Post by: lakeswimr on March 21, 2012, 06:54:24 PM
Do you have a written emergency plan from Dr. Burks?  Does it call for Benadryl before epi ever or does it call for epi, then Benadryl? 

From what I have read from many others posting elsewhere about their emergency plans, allergists are about split on whether they wait for signs of a serious reaction and then have people give epi, followed by Benadryl or whether they tell people to give Benadryl for minor reactions and epi for more serious.  Our allergist calls for waiting to see if epi is needed and not giving Benadryl because he feels it can mask a more serious reaction.  The Benadryl also can not stop a reaction that is going to progress to life threatening from progressing so he feels there is no point to give it and a small risk of masking things.

FAAN published an article in which they stated that Benadryl won't mask a reaction that needs the epi or if it does there will still be enough time to give the epi. 

I think it is 6 of one, half dozen of the other as long as people give the epi for systemic reactions.  The trouble is that many people give Benadryl when they should give the epi, not that some give Benadryl for very minor reactions, in my opinion.

I would look at your written plan and follow it.  If you didn't receive a written plan from a doctor the likes of Burkes I'm very surprised. 

The nurse doesn't sound up to date and I would not be taking advice from her.  Benadryl doesn't stop reactions.  It is for minor  symptoms and for comfort.  It has no life saving capabilities.  most reactions will self resolve even without treatment so the fact that someone survives without the epi doesn't mean Benadryl stopped the reaction.  Also, Zyrtec is way slower than Benadryl and should not be given for anaphyalaxis.  give Benadryl if you are giving an antihistamine.  Also, I think kids normally move up on the epi at about 60 lbs but go up earlier if they have asthma.  If your child doesn't have asthma I would want to stick with the jr but YMMV.  I'd research that.  I agree, her answer would not make me feel reassured.
Title: Re: Bendaryl vs. Epi ... help!
Post by: lakeswimr on March 21, 2012, 07:01:04 PM
Also, it has been a while since I talked about this with DS's allergist but he said something close to this... it can mask early symptoms and if we give Benadryl we might not see hives or an itchy mouth, etc continue outside the body.  Meanwhile, the reaction is continuing to spread silently inside the body and it is building strength but we think the opposite.  And then it comes out big and strong seemingly 'suddenly' and it can certainly have caused us to delay epi because of this.
Title: Re: Bendaryl vs. Epi ... help!
Post by: SilverLining on March 22, 2012, 01:00:27 PM
The time I had my really serious reaction and was treated in the ER, I had not been carrying an epi.  I had taken benedryl as soon as the reaction started (first symptom was hives).  The hives cleared up, but then returned.  It was like a wave, crashing in, then fading away.  Symptoms progressed to anaphylaxis (though I didn't know it at the time). 

After spending a few hours in ER, getting epi and other stuff there, as I was leaving I said to the doctor that I guess the benedryl doesn't work for me any more.  She replied that it had kept me alive til I got there and helped slow the worst of the symptoms.

That's just one person's experience, and one ER doctor's opinion, but I thought it was worth adding into the conversation.
Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on April 03, 2012, 07:41:37 AM
That's interesting about Sicherer relayed to you about epi, Mfamom. When we were
there we got the clear instruction that even with a history of respiratory symptoms from contact to ingestion, if we have a known ingestion (eat peanut) we benadryl first then wait for further reaction. I just yes'd them. I wouldn't wait around too much if he knowingly ate it. We can find out that it's not so bad once we're triaged with monitors and doctors.
Title: Re: Bendaryl vs. Epi ... help!
Post by: Janelle205 on April 03, 2012, 04:17:31 PM
I think that doctor's may be basing a lot of this on individual patient's experiences and history as well.  My doc still advises benadryl, even though I've had a contact ingestion reaction with respiratory involvement.  Luckily though, all of my anaphylactic reactions have been slow moving - I've had a good amount of time to decide to epi.  Things get just as bad for me, but luckily, I haven't had the scary fast, seconds to decide reactions that others have experienced.

To give this info with a grain of salt though, I will say that my doctor gives me personally a lot more latitude with my asthma treatment than he does with other patients as well, because he trusts me quite a bit, and frankly, if I followed the recs that some other doctors had given me regarding asthma, I'd be in and out of the ER once a week, minimum.
Title: Re: Bendaryl vs. Epi ... help!
Post by: 2boyz4me on April 03, 2012, 05:50:27 PM
I'm glad I read this. Holden is at 55lbs at nearly 10 - I'm guessing I should ask the allergist for a change in our script from Epi Jr to Epi??

Title: Re: Bendaryl vs. Epi ... help!
Post by: ctmartin on April 03, 2012, 09:49:33 PM

Hi, Everyone!

Thanks for such great, thought-provoking responses.  In revisiting this thread, I see that I spelled benadryl wrong in the title ... oops ;)

ANYWAY, we did go ahead and purchase the adult epi pen for our daughter,  and based on what has been said here and on conversations with others I feel comfortable in that decision.

I still am a bit confused about the role of benadryl in a reaction, but this confusion has led me to revisit her action plan (yes, macabre, we have the one from burks) which has made things *slightly* clearer.

Basically, it calls for treatment with benadryl for EACH of the following (alone):  skin symptoms (localized hives), GI symptoms, or swelling (even lips and tongue!!).  The only symptoms treated with epi (and benadryl) are a combo of two or more of the above, respiratory distress (coughing, wheezing, etc), and persistent vomiting.

I guess it makes sense:  hives alone could be a contact reaction that might not progress to anaphylaxis.  GI symptoms could be something totally unrelated, but with swelling it seems a bit risky to only give benadryl (?)

What I didn't really understand and was wondering if someone could clarify ... for the symptoms that require an epi pen, benadryl is also checked.  Are we supposed to follow administration of the epi with benadryl as a routine protocol? (we did not do this with her last reaction).  If so, what is the purpose of this??

Thanks! 

Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on April 03, 2012, 10:08:42 PM
Diphenhydramine can really help with nausea.  That would be one reason.

It's also a helpful add-on in terms of blockade at H1 and H2 receptors in cardiac tissues and the GI tract, though it can't effect adequate blood pressure on it's own during anaphylaxis due to loss of peripheral vascular tone.  That's what Epi is for.   

Title: Re: Bendaryl vs. Epi ... help!
Post by: Susan on April 10, 2012, 01:39:24 PM
The issue of antihistamines (Benedryl) vs Epinephrine (epipen) has gone on for quite some time.  I have mentioned this to the AAAAI and they will be issueing and article on this,  I don't know if it will trickle down to us but there you go!

For anaphylaxis reactions the standard advice according to both AAAAI and CSACI is to use an auto injector and call 911.  For localized hives or for contact reactions I can see why one would want to use anti-histamines.

My daughter has enviromental allergies and these we treat with an anti-histamine,  For any reactions due to ingestion or if we aren't sure, we will use an auto-injector.
Title: Re: Bendaryl vs. Epi ... help!
Post by: cmf on April 11, 2012, 07:19:41 AM
antihistamine's WONT stop anaphylaxis as anaphylaxis involves cells other than histamine (mast cells and basophils etc that can cause massive swelling and leakage from tissues that aren't stopped by an antihistamine).
We use Zyrtec because its non sedating and drowsiness can be a sign of anaphylaxis (with low blood pressure you can get 'drowsiness' ie beginning to loose consciousness/finding it hard to keep awake)...so it can sometimes be tricky to see what is antihistamine or allergic reaction progressing to anaphylaxis if you have a sedating one.
Product info for epipen here (aust) is 25kg for junior but all allergist prescribe adult one at 20kg based on current research in management of anaphylaxis.

So....an antihistamine will help the itching and some of the swelling due to histamine release...but if the reaction is going to progress to anaphylaxis then it will happen with or without antihistamine (remember the body produces its OWN adrenaline as a response to allergic reaction...sometimes this is enough to stop anaphylaxis and other times its not...hence our need to always use an autoinjector at the first sign of anaphylaxis as you can never tell what point it will progress to)

edited...tongue swelling should ALWAYS be treated with epipen as it can occlude the airway if it gets big enough (it goes down the back of the throat so will occlude nasal airflow as well). Lips can always be 'opened' to maintain an airway but the tongue is a very different matter-I would get this clarified for your own peace of mind with your allergist.
Title: Re: Bendaryl vs. Epi ... help!
Post by: Carefulmom on April 11, 2012, 02:17:48 PM
Product info for epipen here (aust) is 25kg for junior but all allergist prescribe adult one at 20kg based on current research in management of anaphylaxis.

Is the above a typo?  All allergists don`t prescribe adult epi at 20 kg. In fact, most allergists and pediatricians don`t.  An adult epi is .30 mg which at 20 kg would be .015 per kg.  I just don`t want someone seeing this and getting wrong information about something so important.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on April 11, 2012, 03:51:09 PM
I'm not sure, Carefulmom, but I know that DD was just over 20 kg when she was switched over.
(That's about 45 lbs, yes? 1 kg = 2.2 lbs, or 1 lb = 453 g = .453 kg)

I think that most US allergists are following professional advice to prescribe the higher dose at about 50lbs, or around 23 kg.  It used to be that they didn't switch until much closer to the nominally 'correct' dosage at 66lb, but the risks of underdosing are so much higher than overdosing in someone over 50 lbs, YK?  I think that is why thinking there has changed in recent years.  There has been some rumbling about producing a larger dose for larger adults, as well, because let's face it, a 200 lb guy is going to be massively UNDER-dosed with an autoinjector appropriate for someone my DD's size.

Also want to reiterate why hospitals frequently give diphenhydramine--
remember that the second generation antihistamines are NON-SEDATING precisely because they only hit ONE histamine receptor subtype-- the one that isn't present in CNS and cardiac tissue. 

Unfortunately, that means that during anaphylaxis, diphenhydramine and other drugs in its class have the edge as antihistamine add-ons.  Yes, there is a possibility for laypersons to be confused about the meaning of drowsiness, but in a setting where BP and O2-sats are being monitored, this is a smaller concern than leaving those receptors vulnerable to circulating histamine in a severe reaction.

Therefore, while diphenhydramine cannot elevate blood pressure or open airways (as epinephrine does-- and this is why there is NO substitute for epinephrine for a person experiencing anaphylaxis)... it can serve as an excellent secondary support in management.  Proton-pump inhibitors act at some of the same receptors, and that is why they are sometimes used as supportive medications, too.

Just thought I'd explain the seemingly contradictory advice on this one. 
Title: Re: Bendaryl vs. Epi ... help!
Post by: stpauligirl on April 12, 2012, 01:31:02 PM
My son was switched to adult epi last year, age 7 and barely 50 lbs.

As for Bendryl vs. Epi, the ped allergist said that we could keep benedryl on hand for skin reactions, but it wouldn't stop anaphylaxis. She said she did not include benedryl in my son's school action plan at all, as school nurses (along with everyone else!) sometimes tend to avoid using an epipen, especially if there's another option in someone's school action plan. She said the risks of giving epi to an otherwise healthy kid are minimal; no sense risking it. We haven't even had benedryl in the house. Just my experience, based on my kid's doc's advice for my particular kid.
Title: Re: Bendaryl vs. Epi ... help!
Post by: Carefulmom on April 12, 2012, 02:47:43 PM
My son was switched to adult epi last year, age 7 and barely 50 lbs.

Exactly.  20 kg would be 44 pounds (also replying to CM Deux).  50 pounds is the more common weight to switch (about 23 kg), or even 55 pounds (25 kg).  Some allergists do it at the lower end (20 kg) due to reaction history, but to say that " all allergist prescribe adult one at 20kg based on current research in management of anaphylaxis" is not true.
Title: Re: Bendaryl vs. Epi ... help!
Post by: cmf on April 14, 2012, 08:37:40 AM
oooppps....Im talking about what we do in australia (and yes all allergists here do prescribe it over 20 kg) ....Not a typo..just what is standard here (australia) (under 20kg is .15mg over is .3mg)..but obviously you use what your allergist prescribes you. (the comment was to do with product info which for our epipens states  adult is for over 25kg when in fact we actually have it prescribed by our allergists at 20kg..a standard variation here based on what they believe to be best practice....here).   My point was really to say that product info doesnt always reflect what is considered best practice at the time and sometimes dosages will be adjusted to suit that. ....

"Who should be prescribed the "Junior" version of adrenaline autoinjector?

The Australasian Society of Clinical Immunology and Allergy (ASCIA) Prescribing Guidelines recommends EpiPen®Jr and Anapen®Jr for children weighing 10-20kg and EpiPen®  or Anapen®  for adults and children weighing more than 20kg.

This recommendation is based on consensus and standard practice by ASCIA members and is published in the Australian Medicines Handbook and the National Prescribing Service information on adrenaline autoinjectors.  It is also consistent with recommendations from the American Academy of Allergy, Asthma and Immunology (AAAAI) position statement   www.aaaai.org/media/resources/academy_statements/position_statements/ps34.asp  (this quote comes from here)   http://www.allergy.org.au/health-professionals/anaphylaxis-resources/adrenaline-autoinjectors-faqs....sorry to get off the topic and not wanting to confuse anyone-just sometimes product info is different from what is prescribed (I guess that was the point I was trying to make and obviously things can be very different from one country to another...and nothing beats the advice of your own allergist if at all in doubt. ;)
Title: Re: Bendaryl vs. Epi ... help!
Post by: cmf on April 14, 2012, 08:46:54 AM

Also, she told me that it is time to get Epi, rather than Epi Jr., but the packaging says 65 pounds for Epi, and my daughter is only 44 !

This was what my comments related to.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on April 14, 2012, 09:25:43 AM
Thanks for the clarification!  Yes, there isn't such prescribing recommendation from AAAAI here in the states.  Most physicians who keep up with the field do understand that there is a "hole" in prescribing autoinjectors, where the junior runs the risk of under-dose, and the regular runs presents an over- dose, so an individual physician has to decide which risk if preferable in an individual patient.    :yes:

Title: Re: Bendaryl vs. Epi ... help!
Post by: LinksEtc on March 02, 2013, 04:12:15 PM
Bumping.

Our allergist thought it was time to switch my dd over to the regular epi and she's about 48 pounds.
Title: Re: Bendaryl vs. Epi ... help!
Post by: John on January 21, 2014, 02:04:49 PM
I am an EMT and have a lot of knowlege on food allergies and thought I would clear up some confusion in here.

If you go to the ER for Anaphylaxis, you will get Epinephrine as primary treatment but you will also get IV Benadryl as well, because your body is having a "histamine dump" and the only thing that can stop it is the Benadryl. From the people talking on this board, it seems people think that Benadryl has no place in Anaphylaxis treatment and nothing could be further from the truth. Benadryl is exactly what gets you out of Anaphylaxis. Usual treatment in an emergency room is Epinephrine followed by an IV of Benedryl plus Ranitidine.

My recommendation to those of you with loved ones with allergies, you need to brush up on how histamines work and what works best. If you suspect an Anaphylaxis, then giving them the Epi-Pen is recommended, however, Benadryl cannot HURT your child (unless they are choking and can't swallow). It is specifically what they are going to give to your child after they Epi-Pen them. The Epi-Pen is used to treat the airway constriction and low blood pressure which can lead to death. But the Benadryl is what is used for long term treatment to stop the histamine dump and keep the anaphylaxis from continuing.

If they can swallow, the liquid Benadryl on top of the Epi-Pen give them the best chance at survival (if it's progressing to an Anaphylactic episode). And for what it's worth, the reason Benadryl isn't given as first line is because it takes about 20 to 30 minutes to start working whereas the Epi-Pen is instant.

By giving your child Benadryl, you are not hurting them (just make sure their airway/esophagus isn't constricted). You can only help their situation by counteracting the histamine dump. This doesn't mean you shouldn't also use the Epi-Pen if you need to use it. I know this can be confusing, but it's crazy to hear people talking about Benadryl as if it has no place in Anaphylaxis. It is used in every Anaphylactic episode in the ER - of course it's good for you.
Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 21, 2014, 02:13:34 PM
John, how were you taught to identify anaphylaxis and treat it? Have you ever worked with a board certified allergist and are you familiar with what they write up for patients in something called an EAP (emergency action plan)?

These aren't nonsense questions. I'm sincerely interested in your experience and training as an EMT--whatever level you are. Are you able to administer to patients adult and/or pediatric in your state? I know laws differ.

My kids have anaphylaxed in the allergist's office and of course ambulance and ER. Quite a breathtaking difference in treatment and identification every time.

But this...

Quote
But the Benadryl is what is used for long term treatment to stop the histamine dump and keep the anaphylaxis from continuing.

Where did you get that? Because even the use of prednisone to prevent the further degranulation of mast cells post-incident is at best likely, not guaranteed. You're going to have to support that statement with something SOLID. If you're talking just its symptom controlling anti-histamine effects that's different. But preventing anaphylxis no can do.

Anyhow, I won't have time to say this later so I have to do it now.

As patients we get different marching orders from our allergists for emergency action in the field. You may think you're in the field. You're in a truck prepped with lots of equipment with 2-3 of your best trained friends in that equipped vehicle that also has a radio and the ability to drive like a bat out of hell to a the ER where we meet even more trained people with lots of medication and equipment.

You know what we have as parents/patients? An epinephrine autoinjector, some Benadryl and keeping it together to follow the emergency action plan that our allergists give us based on best known practices. Mortality decreases positively with the prompt administration of epinephrine. Technically, epinephrine isn't going to hurt you, either, which is why as a medical discipline immunology tells us to not be afraid of administration upon recognizing anaphylaxis or even asthma unresponsive to rescue inhalers. Similar to a patient who presents with similar symptoms of asthma, anaphylaxis needs recognition as rescue inhalers are not going to treat it.

So as an EMT of whatever grade you're part of the equation but not the one between the allergist and the patient. That's really what is being discussed here. Not that your input isn't appreciated, any increase in knowledge is a positive gain. But do realize we aren't advised on IgE-mediated allergies by EMTs but board certified immunologists whose treatment plans for patients WITHOUT medical personnel and equipment is different than your vocation, equipment and resources.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on January 21, 2014, 02:38:41 PM
John, you might need to read the thread again-- nowhere does anyone suggest that diphenhydramine is harmful.  There are also a physician, a pharmacist, and a research pharmacologist who have all weighed in just in this thread alone.  (wow-- I just realized that there MUST be a punchline in there somewhere, surely... ;)  )  I'm very confident that the latter individual and most likely both of the former probably possesses at least as good a basic understanding of histamine and receptor blockade as you have.  :)

I think that in practical terms, physicians often go with "no benadryl" in emergency action plans because otherwise, there is a very real fear that laypersons in charge of management (before people like you ever even get there) may DELAY administration of epinephrine too long.

Think about it-- it's just you, and a bottle of benadryl and two autoinjectors.  What do you do when you see grade II symptoms?

Better think fast.

Wait and see?  Give benadryl, maybe see if that helps?  Peak concentrations there are about 15-20 minutes out, yeah?  So you won't see maximal benefit until then... probably okay to wait and see if it resolves then, right?  At least if you don't see OTHER worrisome symptoms developing, right?


Er--

no, actually. Tragically, I might add.


YES, most anaphylaxis is self-resolving.  Most anaphylaxis is a steady slow-moving freight train of clear symptoms.  But not always.  Getting it wrong means that a loved one, often one's own child-- dies.

So yeah, the physicians that care for patients who are at extreme risk for anaphylaxis do often tell parents (and other caregivers) to be trigger-happy with epinephrine, and to leave the benadryl out of the equation, which is complicated enough with only epinephrine under consideration.

http://www.the-clarkes.org/stuff/ana.html

Having a clear yes/no decision tree is essential for parents and school personnel.

This is a matter of simplifying instructions for those who may lack training-- and almost always lack additional resuscitative ability/equipment.   Fine for those who have the ability and expertise to conduct their own volumetric resuscitation if they turn out to be WRONG in the end, but for most of us, that is going to be game over unless it happens in an ER setting.





Title: Re: Bendaryl vs. Epi ... help!
Post by: maeve on January 21, 2014, 03:11:15 PM
I'm a layperson, but I'll relay what we've been told by our allergist at Johns Hopkins. Benedryl is not a life-saving medication with anaphylaxisis. It can treat symptoms (hives, itchiness, nausea), but it does not stop the reaction. The only medication that can stop anaphylaxsis is epinepherine. I'll also concur with twinturbo, that as a parent I am following the action plan developed by my child's allergist. Now we also have a comorbid condition: asthma. Having asthma makes it much more likely that my DD will have a quickly progressing anaphylactic reaction. We will never hesitate to give her the EpiPen right away and have instructed her caregivers to do the same.
Title: Re: Bendaryl vs. Epi ... help!
Post by: Macabre on January 21, 2014, 03:12:41 PM
Neither my son nor I have had Benadryl administered at the ER after using the EpiPen or en route (he's had Epi 4 times? Maybe more.  A I had it most recently December 2012). I had a second dose if epinephrine, pred, and Zantac given to me. Or wait--Zantac was prescribed by my allergist after rather than given in the ER.

I did get the sense that not all emergency responders treat anaphylaxis uniformly in transport. And I have experienced very different treatments of it the ER over the years.

It would be great if there were a consistent standard of care. 
Title: Re: Bendaryl vs. Epi ... help!
Post by: LinksEtc on January 21, 2014, 03:29:30 PM
I'm just going to put this link in here ...


http://allergicliving.com/index.php/2013/08/22/lessons-from-a-teen-food-allergy-tragedy/


Dr. Wood:
Quote
Antihistamine is a useful medication for some relief of symptoms such as a few hives, but has no capacity whatsoever to prevent or control more serious allergic reactions. If a reaction is going to progress, the administration of Benadryl will not help to prevent any real progression.


Dr. Waserman:
Quote
In Canada’s guidelines, we don’t support the use of Benadryl if symptoms are developing in response to the accidental ingestion of food. However, some allergists will disagree with me.
Title: Re: Bendaryl vs. Epi ... help!
Post by: John on January 21, 2014, 04:19:10 PM
This is not advising people to not use an Epi-Pen! I think you are misunderstanding me. The first thing you should do is call 911 and give an Epinephrine shot. Antihistamines are considered adjunct therapy but they are not without their place when understanding severe allergies and the way the body reacts.

Again, my goal here is not to advise people not to follow an action plan. My goal here is to educate people on why Benadryl can be an important drug in your arsenal. You should absolutely follow an action plan and your doctors orders. What I'm advising people is to read up on anaphylaxis treatments and why certain things are done.

As always, the emergency room is always the first priority. If you are camping with your kids in the woods and you only have an Epi-Pen on you, I highly recommend people to also have some liquid benadryl, that's all I'm saying. Some people, many actually, may disagree with that and that's fine.

The reason why there are so many different types of treatments given are because most parents are extremely cautious (which is fine by me) but the first sign of their kid with a red bump and they are reaching for the epi-pen. What parents need to do is learn how to watch their kids for signs of progression rather than giving their kid an injection any time they sneeze.

I know some people adhere to the "better safe than sorry" guidelines, but if you are quick to act when you see their status deteriorating, then you will never be sorry. The key is to read, watch somebody for signs of progressions and more importantly keep a calm head.

I read about the food allergy tragedy link you posted LinksEtc and yes, that can happen. But the other thing you have to remember is that only 100 people or so die every year from food allergy anaphylaxis. It's rare. Yes, it's good to be safe than sorry, but part of living life is risk. You can die from walking across the street but it doesn't stop you from taking the chance.
Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 21, 2014, 04:36:59 PM
Red bump and sneeze? Can we use more precise terms as per anaphylaxis grading? Let's come off the silliness. And surely you're not giving medical advice to people over the internet.

I want to make the next statement very carefully worded. You as an EMT are here to explain carrying and administering epinephrine to children is the result of "extremely cautious" parents. And you, EMT on the internet, know better about allergies than the researcher immunologists whose patients we are (or are children are), and whose publications we read in peer-reviewed medical journals.

Way too many personal feelings you have in regard to judging when these are no patients of yours. I highly suggest taking some time out to query either AAAI.org to send in some questions regarding patient EAPs, or spend some time in the office of a good board certified pediatric allergist.

Does your boss know you're doing this?
Title: Re: Bendaryl vs. Epi ... help!
Post by: LinksEtc on January 21, 2014, 04:53:05 PM
But the other thing you have to remember is that only 100 people or so die every year from food allergy anaphylaxis. It's rare. Yes, it's good to be safe than sorry, but part of living life is risk. You can die from walking across the street but it doesn't stop you from taking the chance.


 ;D

We've had discussions about this here also.


Let's talk about anxiety

"If food allergy deaths in food-allergic individuals are rare, do we change our ways?"
[url]http://foodallergysleuth.blogspot.com/2013/12/if-food-allergy-deaths-in-food-allergic.html[/url]
Quote
The study authors certainly have noble intentions of this study reducing the anxiety faced by food allergic individuals or their caregivers.


"FOOD ALLERGY: A LOT IS RIDING ON OUR TIRES"
[url]http://www.allergyhome.org/blogger/food-allergy-a-lot-is-riding-on-our-tires/[/url]
Quote
For me, their findings convey the unlikelihood of a fatal anaphylactic reaction if appropriate management strategies are implemented, and provide me with some reassurance.

(FWIW, I liked the way he framed this.)

----------------------------------------------------------------------

Also, ana itself does not appear to be rare:
"ANAPHYLAXIS IN AMERICA"
[url]http://www.aafa.org/display.cfm?id=6&sub=110&cont=882[/url]
Quote
According to the peer-reviewed study, anaphylaxis very likely occurs in nearly 1-in-50 Americans (1.6%), and the rate is probably higher, close to 1-in-20 (5.1%).

Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 21, 2014, 05:01:08 PM
I'm printing John's posts out for the next appointment with allergist showing in the words of an EMT what he thinks of the EAP, carrying and administration of epinephrine. Then I'll finally get that letter on practice letterhead from allergist to give to EMTs I've been asking about. He didn't believe me that rift between allergist and EMT exists. Got proof now!

Saving for the record to use at appointments, school meetings, what have you. Voluntary, written, first person, on a public forum.

Spoiler (click to show/hide)
Title: Re: Bendaryl vs. Epi ... help!
Post by: LinksEtc on January 21, 2014, 05:01:48 PM
The reason why there are so many different types of treatments given are because most parents are extremely cautious (which is fine by me) but the first sign of their kid with a red bump and they are reaching for the epi-pen. What parents need to do is learn how to watch their kids for signs of progression rather than giving their kid an injection any time they sneeze.

I know some people adhere to the "better safe than sorry" guidelines, but if you are quick to act when you see their status deteriorating, then you will never be sorry. The key is to read, watch somebody for signs of progressions and more importantly keep a calm head.


Most of us on this board see very good allergists and we usually just follow their instructions as written on our allergy plans.  Depending on factors such as reaction history, whether asthma is a factor, the allergen (ex - peanut), etc. .... they advise us how we should treat symptoms such as hives.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on January 21, 2014, 05:14:36 PM
Quote from:  guest John
The reason why there are so many different types of treatments given are because most parents are extremely cautious (which is fine by me) but the first sign of their kid with a red bump and they are reaching for the epi-pen. What parents need to do is learn how to watch their kids for signs of progression rather than giving their kid an injection any time they sneeze.



Patronizing, much?

Thanks, but most of us here have gotten this SAME nasty attitude from friends and family.  Make that former friends and estranged family.  We really aren't totally loony.  A fair number of us see physicians who are leaders in the research associated with this field clinically, by the way.  :)

How many times have you WITNESSED food anaphylaxis from start to finish?  Not many, I'm guessing.

Now I'll report to you what MY allergist has had to say on the subject of early epinephrine and first responders such as yourself:  basically, I should know better, since YOU most likely won't have a clue if my child isn't COVERED in hives and struggling to breathe.  At least not until she arrests, and even then you'll most likely be arguing with me about how with no cutaneous symptoms, this can't possibly be anaphylaxis...  in other words, don't waste time arguing when time is brain function-- preempt the entire conversation with DIY before they show up.

If you'd read the link about Natalie Giorgi's fatality, you'd know that her father was treating her on the scene-- her father being a PHYSICIAN.  Wait and see is dangerous.

The vast majority of parents and adults who post here have experienced anaphylaxis firsthand, often more than once, and more than a few of us have been LUCKY to survive grade IV-V reactions.  With all due respect, our risk here is a little bit higher than that "enjoyed" by most people just crossing the street.  My teenaged daughter can probably (best case scenario) expect to experience another 8 to 14 episodes of anaphylaxis in her life. Statistically speaking, I mean.  Given her history, her odds of experiencing a  life-threatening reaction that requires a 911 call are... almost inevitable.

Some additional enlightening reading on this subject:

No, actually-- epinephrine "over-use" is not really a thing.

Quote
Dr. Jacobsen's team surveyed 3500 nationally registered paramedics in the United States and found that 36.2% of responders felt there were contraindications to the administration of epinephrine for a patient in anaphylactic shock.

"They also had challenges in the recognition of atypical presentations of anaphylaxis and determining the correct location and route of epinephrine administration," he said.

Only 2.9% correctly identified the atypical presentation, 46.2% identified epinephrine as the initial drug of choice, 38.9% chose the intramuscular route of administration, and 60.6% identified the deltoid as the preferred location (11.6% identified the thigh).
 
We have the same issues in the United States that were found in the Canadian study.
 

"Our study also revealed that 40% of paramedics believed that diphenhydramine was the first-line medication for a patient suffering from anaphylactic shock," added Dr. Jacobsen.



Well, well. Now perhaps it is clear why my own allergist feels the way that s/he does about first responders and atypical presentation, eh?  It's ON US as patients/parents to treat with epinephrine before an EMT rolls up, because the odds are far too high that they WON'T.  Until it's too late, I mean.

No, over-use  really isn't a thing-- I promise.

Underutilization most assuredly IS, however.



 
I'm printing John's posts out for the next appointment with allergist showing in the words of an EMT what he thinks of the EAP, carrying and administration of epinephrine. Then I'll finally get that letter on practice letterhead from allergist to give to EMTs I've been asking about. He didn't believe me that rift between allergist and EMT exists. Got proof now!


Indeed.  Well, he knows.  He just overestimates the ability of mere mortals to GET THROUGH TO THEM, because he happens to actually have those magical letters "M.D." behind his name, and forgets that it matters, even if he's acting in the capacity as "dad" at the time.  But it's why he's given me the advice that he has.  Epi early and often-- before the "pros" show up and dismiss everything that you know (that they don't).






John-- PLEASE consider carefully reading the following:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096462/




Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on January 21, 2014, 05:26:06 PM
This has several highly instructive entries, with nice citations and commentary throughout:

http://certifiedallergysa.com/wordpress/tag/epipen/?wpmp_switcher=desktop


I really recommend that to everyone. 
Title: Re: Bendaryl vs. Epi ... help!
Post by: John on January 21, 2014, 06:00:12 PM
John-- PLEASE consider carefully reading the following:

ncbi.nlm.nih.gov/pmc/articles/PMC3096462/
[/quote]

Thanks CMDEUX, just read it. This is what stood out to me like big red neon letters which pretty much covers the mentality of many at this board.

"Fortunately, food-allergy induced fatalities remain rare, although fear of fatal reactions contributes to the anxiety that exists in families with a food-allergic child."

Somebody mentioned loony earlier and I wouldn't be so quick to discount that. Just because you keep jabbing your kid with an Epi-Pen it doesn't mean that you are keeping them safe. Did your allergist also talk with you about the risks involved? Oh wait let me guess, the risks outweigh the potential for death right?

Food allergy obsessed people are just the second coming of "fever phobia" people who throw their kids in ice baths when they have 102 fever. Just as febrile seizure is rare, so is death from a food allergy. But hey, keep giving your kid an epinephrine shot every time he gets a perfectly normal rash.

I'm sure his/her heart will be in great condition once they reach 21 from dosing on Epi-Pen 52 times a year.
Title: Re: Bendaryl vs. Epi ... help!
Post by: John on January 21, 2014, 06:07:09 PM
Only 11 people died from food allergies in 2005. Previous reports of 150 people dying per year are miscalculated (please see article at Huffington Post entitled "Food Allergy Deaths: Less Common than you Think."

To put in in perspective: 250 kids drown in swimming pools in 2004.

In the U.S. 16 people got bit by sharks in 2005.

51 people are killed by lightning every year in the US.

Are you going to force your kids to stay indoors when it's raining for the rest of their lives?
Title: Re: Bendaryl vs. Epi ... help!
Post by: John on January 21, 2014, 06:10:32 PM
I'm printing John's posts out for the next appointment with allergist showing in the words of an EMT what he thinks of the EAP, carrying and administration of epinephrine. Then I'll finally get that letter on practice letterhead from allergist to give to EMTs I've been asking about. He didn't believe me that rift between allergist and EMT exists. Got proof now!

Saving for the record to use at appointments, school meetings, what have you. Voluntary, written, first person, on a public forum.

------------------------------------------------------------------------------------

For the record, I never said anything about not dosing epinephrine. I stated that Benadryl has its place in the treatment of any allergic reactions up to and including anaphylaxis. With Epi-Pen being the primary treatment before anything else (besides calling 911).

You guys are unreal.
Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 21, 2014, 06:16:50 PM
Do you think you should calm down a bit before coming back to this? 
Title: Re: Bendaryl vs. Epi ... help!
Post by: Janelle205 on January 21, 2014, 06:48:24 PM
Two things:

1) I haven't been around here forever, but for a while.  Never have I heard one of the parents here, or adults with FA, talk about using epi for just a rash.

2) It's great that there are not a lot of FA deaths each year.  However, that statistic means a lot more to the general population than the self-selecting group here.  The people here (those with FAs themselves and parents) are associated with individuals that are WAY more likely to have severe/adverse reactions than the general population.  If this wasn't a significantly life altering (and life-threatening) condition, I would not have sought out a support group.
Title: Re: Bendaryl vs. Epi ... help!
Post by: Macabre on January 21, 2014, 07:07:38 PM
John, I think your initial post about Benadryl was helpful to some degree.

Truthfully, practically all if us use it when appropriate (there is a concern for some Benadryl formulations for those with a dairy allergy, as they contain milk).

It may have it's place in anaphylaxis, but as you said initially it would be secondary to epinephrine. Frankly, my EAP calls for Epi then feet above heart. In certain situations (if I had it available and if I were worried emergency transport were not arriving soon enough (happened with my son), I might take a hit of Benadryl, but my allergist has expressed concern that using Benadryl could mask anaphylaxis symptoms. So I worry about that. But 99% if Benadryl is going to be used in anaphylaxis after Epi, it would be because medical personnel would administer it, not because I'm going to go against my board certified allergist's plan. And in 5 or 6 trips to the ER for anaphylaxis (my son had a biphasic rxn 8 hours later that required a second Epi and transport, so two those were in one day) neither my son nor I have been given Benadryl in the ER.

The worrisome fact is that for a great many parents of children with food allergies, they think Benadryl is sufficient. They don't carry epinephrine. I will come back and support that with data (On my phone now). If you look at deaths of FAs , the majority of them either did not have epinephrine with them or did not use it soon enough.

The peer reviewed medical literature supports using the Epi sooner rather than later. (I'll provide a lion later).

The group here is not a bunch if EpiPen happy munschausen moms. In fact, we do everything we can to prevent having to Epi. It's not a get out if death free card.

Fwiw, a study last winter found that emergency responders do not recognize anaphylaxis by and large (I will insert the link).

I found this to be the case personally. In Dec 2012 I inadvertently consumed sesame and started experiencing runny nose, hives, stomach cramping, trouble breathing (I'm asthmatic) and my Eustachian tubes swelling. Also eventually got that impending doom sense. This was anaphylaxis. I called my husband and he talked me through the injection (I had used the Epi on myself once before and my son, now 15, twice, but it is hard to convince myself sometimes).

Per my EAP, I lay down with my feet above my heart and called 911. The EMTs arrived in 5 min and took me to the hospital. I remember on the way having a difficult time forming sentences. I felt very confused.

Once I got to the ER, a biphasic reaction began to occur. The we doc gave me more epinephrine. He gave me pred as well. Upon leaving several hours later,  he told me to take Zantac and gave me a pred script.  I continued to have uterine contractions for a few days.

(BTW--no Benadryl, intravenous or otherwise, was given to me. This was one of Minneapolis' premier hospitals.)

The doctor wrote in my discharge a dx of anaphylaxis.


When my insurance company did not pay for my transport, they said because it was not medically necessary--because the EMTs wrote that I had a minor allergic reaction.

The doctor diagnosed anaphylaxis. I gVe the Epi because I had reactions from more than one body system, which indicates anaphylaxis.

So I think you'll understand if I don't simply buy what and EMT says I need to do.

Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on January 21, 2014, 07:09:45 PM
I've already inserted a number of those same links, Mac!   :thumbsup:



 We do get trolls, folks.  Yes we do.     ;)

Of course, it's only term break right now for college and high school students on SEMESTERS.  So expect more of this sort of thing come the quarter-break in March.  LOL.
Title: Re: Bendaryl vs. Epi ... help!
Post by: lakeswimr on January 21, 2014, 07:33:33 PM
John, you started out telling us that Benadryl was an important 2nd step for the prevention of a reaction continuing and that giving it via IV is standard procedure.  People showed you the current National Institute of Health's guidelines which contract what you claim.  The guidelines say that Benadryl has no life saving capabilities and is for comfort only.  You then switch to saying that we and others dealing with food allergies are all giving the epi for minor symptoms.

You sound as though you got trained by someone who was no up to date on the most current recommendations for treating anaphylaxis and that is fairly common.  I'd recommend you take the NIH guidelines over whatever training you had.  You are not a doctor.  You are not an allergist.  You are not a specialist in food allergies.  You are someone who has a very important job and must be a generalist in knowledge.

Your posts reflect someone who is just  not up to date.

And you assume a lot.  I know that most anaphylaxis self-resolves even without treatment.  The trouble is that sometimes it does not and most of the very worst reactions start as minor.  So, when my child has food allergic reactions I watch and wait and only if warranted based on my son's emergency care plan, do I epi.  And I try to always epi if my son's plan calls for it but even then my response is to want to not have to epi.  I have failed to epi more times than I have given it. 

Thanks for your advice but I will stick to following my emergency care plan that I got from one of the top allergists in the world.  I recommend you stay open to the idea that things change and you must stay up to date in order to know how to best care for patients.
Title: Re: Bendaryl vs. Epi ... help!
Post by: lakeswimr on January 21, 2014, 07:34:34 PM
The big change in claim from being an EMT who is pushing for the importance of Benadryl to someone trying to convince us that we are epiing too much and that the epi isn't needed as the risk of not doing so is remote also made me think troll but who knows.
Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 21, 2014, 07:47:19 PM
Or he flipped out and lost control on his day off. It is a stressful job contributing to PTSD and depression. I don't think he's a troll I think he had all these feelings bottled up and got stuck not being able to run on sheer feeling when confronted with objective, credible information.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on January 21, 2014, 11:18:17 PM
The big change in claim from being an EMT who is pushing for the importance of Benadryl to someone trying to convince us that we are epiing too much and that the epi isn't needed as the risk of not doing so is remote also made me think troll but who knows.


Agree-- kind of erratic, that rant-- and a large part of me HOPES troll.



Quote
Somebody mentioned loony earlier and I wouldn't be so quick to discount that. Just because you keep jabbing your kid with an Epi-Pen it doesn't mean that you are keeping them safe. Did your allergist also talk with you about the risks involved? Oh wait let me guess, the risks outweigh the potential for death right?

{snip}
I'm sure his/her heart will be in great condition once they reach 21 from dosing on Epi-Pen 52 times a year.

That's the wikipedia level of pharmacology here, I suppose.   I've speculated about this (IRL, not here); that first responders and ER physicians may well regard epinephrine from a pharmacy-tech level viewpoint as "oh, epinephrine...   = powerful cardiac drug!  elevates BP and pulse rate!" when that is not a very nuanced (or, as it happens, CORRECT) way of looking at that molecule in the first place.  Other pharmacologists (including cardiac pharmacologists in particular) agree with me wholeheartedly, as have many of the cardiac clinicians I know.  It's an interesting consideration which I find academically interesting-- except for the unfortunate sequelae that matter to me as a patient and mom (that being that it's NOT seen as a first-line therapy due to reluctance to let go of "drug of last resort" and "powerful").  It's interesting to note how differently EMT's, Nurses, and Physicians view drugs; they see a constellation of symptoms and up and down arrows associated with them, I think.  Pharmacologists think in feedback loops and receptor-ligand specificity and binding on/off-rates.  Just different.  So yeah-- I'm not the least bit intimidated by beta agonists.  Well, less so than other things, like muscarinics and some ion channel blockers.  LOL.     


 By the way, since we're discussing benadryl?  H1 blockade is itself not without risks.   Those risks are somewhat comparable to low-dose IM epinephrine, actually.   H2 blockade is still not entirely clear, in terms of mechanistic benefit during anaphylaxis, but it doesn't seem to carry the cardiovascular risk of H1 blockade.   H1 = benadryl and H2 = ranitidine, in layman's terms.

I'm also wondering if John knows why EPI is preferred over other beta agonists in treating anaphylaxis, and about drug interactions (beta blockade comes to mind immediately, but also some cholinergics-- whoooboy, check out the fine-fine-FINE print on promethazine-- that one takes a lot of docs and pharmacists by surprise, even) that make treatment of anaphylaxis much trickier pharmacologically.   


If I'm wrong about this person being a troll, then I sincerely hope that our guest will avail himself of CME credits and get a little more education about anaphylaxis and its mediators.  Oh-- and cardiac pharmacology, since he seems to believe that epinephrine has serious risks when administered IM, and this (seems) to be a possible barrier to care, professionally, given its other uses therapeutically, where it has few substitutes.       

    I hope TT is right, and that John is just having a really really bad day-- and really, better here than unloading on some poor mom or dad while hauling their kid away.   We've all pretty much been there with a bad day, I think. 



Title: Re: Bendaryl vs. Epi ... help!
Post by: lakeswimr on January 22, 2014, 08:50:30 AM
Oh, and I didn't see the 52 times a year thing.  Wow!

My son's allergist did talk to me about the risks of giving the epi vs not giving it and it is a topic that has been studied and written about by many top allergists and food allergy researchers and the NIH, etc. Giving the epi is regarded as much safer than not giving it in the case of a systemic allergic reaction.  The risks of the epi are very small and it is considered safe for all those except people who have heart conditions.  It used to be standard treatment for asthma and has a long history of being used.

I have had EMTs, ER nurses, etc focus on benadryl and freak out about it, "we have GOT to get this kid Benadryl!"  So, I do not think John is alone in his false belief that Benadryl has life saving capabilities.  It's unfortunate since one day one of his patients may be in need of a 2nd (or from the sound of recent posts a first) epi and he may not give it.  I sure hope not. 

Title: Re: Bendaryl vs. Epi ... help!
Post by: rebekahc on January 22, 2014, 08:57:40 AM
I've already inserted a number of those same links, Mac!   :thumbsup:



 We do get trolls, folks.  Yes we do.     ;)

Of course, it's only term break right now for college and high school students on SEMESTERS.  So expect more of this sort of thing come the quarter-break in March.  LOL.

I suspect "John" may be more than an ordinary troll.  I think he's out to prove to his friend/family member that she's overreacting with her child's recent anaphylactic reaction.
Title: Re: Bendaryl vs. Epi ... help!
Post by: PurpleCat on January 22, 2014, 09:13:50 AM
John, I don't know what state you are from or who the doctor is who gave you the information.  I do know that not all EMT's or Paramedics are well trained in dealing with anaphylaxis.

Here is what my most recent experience was with an excellent Paramedic from our town.  Almost a year ago, my teen had anaphylaxis to sesame flour in a bread at home.  Her reaction started with an itchy mouth....we did not know at the time what prompted it so I gave her benedryl as she also has OAS to some fruits and vegetables and maybe this was a new one.  About 20 minutes later she threw up (which she does from cross contamination with egg) and felt much better but tired.  Then as she rested she started getting mucus in her mouth....immediately - epi and 911, both had been in my hands the whole time.  Our town's emergency response was superb - police, fire, and ambulance.  In the ambulance she got an iv and they monitored her vitals and watched her asthma.  The specific allergen, determines how anaphylaxis will progress for my child...her body behaves differently for each one.

She remained stable, at the hospital they gave her more epinephrine, predisone, and something to settle her upset stomach....I don't remember what that was.  The Paramedics stayed for a bit.

My DD got weird and I knew something was wrong, I ran out and grabbed the doctor, nurse and paramedic who were discussing DD.  By the short time they got in the room she was covered in the biggest hives I have ever seen, out of control itching and having difficulty breathing.  She looked horrid.  They did what needed to be done and she calmed after getting a breathing treatment.

A month later, the Paramedic asked me about the second reaction at the hospital.  He had never seen that and did not know that kind of reaction was possible based on the situation and how stable DD was.  He genuinely wanted to learn from what he saw and what I could tell him about how my child experiences anaphylaxis.  We had a great conversation.  I told him I had never seen hives that big on DD.....size of softballs, even on her scalp!  She looked like a horrible topical relief map.

My point to all this is if you have come to learn, you will learn much from us.  We live this everyday and we dread a reaction....but when it happens, we know how best to treat our child based on experiences and what our allergists have taught us.  It is not textbook, it is not black and white, and I think your original post should be identified as "your opinion, or your practice" but not as what every person should do.  In my opinion, without that disclaimer, it is not safe advice for some of our new parents who are looking for answers and solutions.

Welcome, join our conversations, learn and share, we are a good group of adults and parents with children dealing with allergies
Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 22, 2014, 09:59:09 AM
Just for sake of structure and because it directly relates to who may administer (a) epinephrine to adults (b) epinephrine to pediatric patients by law per state.

EMT Basic (most common)
EMT Intermediate
EMT Advanced
Full paramedic often shorthanded as medic

The training is not the same, the knowledge and experience is not the same. In some programs one may take the EMT Basic without the actual hands on clinic but I think any of those are not allowed to apply for jobs that function as EMTs.

In my current state all EMTs may administer epinephrine even to pediatric patients as far as I know. In my previous state only full paramedics could and they were very few. Typically I find that EMT A, paramedics and ER attending physicians are more in line with NIH standards and current best practices with regard to epinephrine as it pertains to immunology, anaphylaxis and EAPs. Those are the ones that usually 'talk shop' openly.

I doubt few paramedics would identify themselves as an EMT and probably more as "medic". But that's anecdotal based on the medics I know in social circles.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on January 22, 2014, 10:11:23 AM
 :yes:

EMT B here is:  pass knowledge exam ---> graded practicum ---> certification.


Just to clarify this point, as well-- there are no absolute contraindications to IM epinephrine for the treatment of anaphylaxis.  Not even cardiac ones. 

Concerns about epinephrine as a drug often as not revolve around IV administration, which IS much more hazardous.  IM administration is quite safe.



Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 22, 2014, 10:28:18 AM
Again, anecdotal, but in talk with previous pediatrician who was one of the types to talk to a patient as a colleague as long as you could keep up with him we covered the difference of knowledge and use of epinephrine (specifically the fear of it within some first responders) in pediatric patients presenting with anaphylaxis.

Hashing it out we surmised it's because many first responders see so many patients with pre-existing cardiac conditions which leads them to erroneously assume if an elderly person with a weakened heart is prone to a strong beta agonist then surely a pediatric patient must be at equal or more risk not realizing it's contrary to that belief.

This is one of those areas that really FARE probably needs to gain speed on to make sure the discipline of immunology, its best practices, NIH guidelines, critical care and first responders of ALL level and training should align.

By the way it's worth mentioning that THIS thread is about epinephrine. For coverage of the wide array of antihistamines (or even prednisone for those of us who are using it post-reaction or for other reasons) then take 5 seconds to use the search function to find and read the conversations about them. Many of us are using daily antihistamines such as Zyrtec, Claritan and Allegra to use their trade names and Benadryl as part of our EAPs.

My tolerance for hyperbole, false dichotomy, straw men, ad hominem and garden variety BS without showing the least bit of professionalism and demonstrable knowledge when queried with cold hard fact from both well read individuals and/or the pharmacology professionals who can themselves mint other pharmacology professionals through PhD levl, is worn thin.
Title: Re: Bendaryl vs. Epi ... help!
Post by: maeve on January 22, 2014, 11:48:35 AM
Quote
but the first sign of their kid with a red bump and they are reaching for the epi-pen

What a terribly dismissive statement. I have never administered the EpiPen for a "red bump" or even for an area of localized hives. Goodness a stray red bump could be anything in an atopic child who is prone to eczema as well as contact reactions. 

Title: Re: Bendaryl vs. Epi ... help!
Post by: maeve on January 22, 2014, 11:59:27 AM
John-- PLEASE consider carefully reading the following:

[url]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096462/[/url]



Totally off topic.  Oh, we saw the author of that study when she was doing her fellowship with Dr. Wood.  We loved Dr. Keet. Honestly, all of Dr. Wood's fellows are top notch. Dr. Keet now does research at Hopkins. Dr. Sharma, who writes for the American Allergic Living, was also one of Dr. Wood's fellows and now heads up pediatric allergy at Children's in DC.
Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on January 22, 2014, 12:00:58 PM
Yes, it's a really top-notch review article.  VERY detailed and thorough examination of what current is (and is not) known about the allergic cascade and relevant pharmacology.   :heart:
Title: Re: Bendaryl vs. Epi ... help!
Post by: Janelle205 on January 22, 2014, 01:45:31 PM
You know, if someone actually was having to epi themselves or their child once a week, as you suggest, they likely really need to review their management practices.


Upon further reflection, I said that I wouldn't epi for just a rash.  That's not necessarily true.  If I had a rash and found out that I had somehow consumed something with apple in it, I would go ahead and epi, no waiting, no questions asked.  But that is my plan (approved by a board certified allergist), and if I've come into contact with something with apples, I've played this game enough times to know where it is going.
Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on January 23, 2014, 07:39:01 PM
Everything You Wanted to Know About Epinephrine and More 
Wednesday, February 26, 2014 at 7pm Eastern (4pm Pacific)

Register: https://www4.gotomeeting.com/register/170327023

 

Angela Nace, PharmD, author of our very popular Epinephrine Comparison blog post, and Michael Pistiner, MD, MMSc, Chair of KFA's Medical Advisory Team and frequent guest speaker on our webinar series, will answer your questions about epinephrine.  Submit your questions in advance on the registration.  We thank Mylan Specialty for sponsoring this event.
Title: Re: Bendaryl vs. Epi ... help!
Post by: LinksEtc on April 30, 2014, 09:46:49 AM
"Safety of epinephrine for anaphylaxis in the emergency setting"
http://www.wjem.org/upload/admin/201311/d095a4afd3dc3f7fc3baa8d33a54d10b.pdf

Quote
Why not antihistamines or corticosteroids first?

Quote
There is no evidence that they provide life-saving treatment (i.e. they do not prevent or relieve upper airway obstruction, hypotension, or shock).[24] Antihistamines [IM or intravenous (IV)] are adjunctive therapies and may be tried after epinephrine is administered to help control cutaneous and cardiovascular manifestations, such as itching, flushing, urticaria, angioedema, and nasal and eye symptoms, as well as prevent secondary reactions.


Title: Re: Bendaryl vs. Epi ... help!
Post by: twinturbo on May 01, 2014, 11:36:09 AM
I'm tinkering with getting my EMT basic this summer. This'll come in handy during "that" portion. I should ask Silver how her son handled it, continues to handle it in the field.
Title: Re: Bendaryl vs. Epi ... help!
Post by: LinksEtc on May 18, 2014, 10:37:18 AM
Tweeted by @Allergy

-----------------------------

"Anaphylaxis treatment: current barriers to adrenaline auto-injector use"

http://onlinelibrary.wiley.com/doi/10.1111/all.12387/full?utm_content=bufferb6b2b&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer


Quote
Limited awareness of the treatment of anaphylaxis by health professionals

Data from several cohort studies illustrate the extent of under-treatment of anaphylaxis and the low rate of adrenaline use [12, 15, 39-41], with most cases of anaphylaxis that require hospitalization not receiving an AAI on discharge. Adrenaline is much less commonly used than antihistamines and corticosteroids in treating anaphylaxis despite both antihistamines [42] and corticosteroids [43, 44] having an onset of action that is delayed and too late to prevent respiratory and/or cardiovascular arrest, which can occur within minutes [23].

Title: Re: Bendaryl vs. Epi ... help!
Post by: candyguru on May 18, 2014, 10:58:34 PM

This is the procedure we have followed in the past.

Siena (age 5 at the time) ate a product with lentils.  She did not feel well (we did not know of her lentil allergy at that time).  Called 911.  She felt weak and had a stomach ache and was lying down and had a cough.  We gave her epi-pen.  No hives. Firefighters arrived in about 4 minutes.. 2 mins later, ambulance arrived - took her to North York General Hospital.

Upon arrival the doctors gave her epi-pen #2 (about 15 mins after epi-pen 1).  They hooked her up to an IV and gave her steroids and benedryl.... kept the IV attached for 5 hrs.  After being discharged, she received steroid prescription for following 3 days.

There were no hives until after we arrived at the hospital, when only a few small ones appeared.  But even in the absence of hives, we knew right away she needed the epi-pen, and when we got to the hospital the E/R doctor knew she needed a second epi-pen. (actually, epi-pen jr)

After dealing with allergies all these years, we are probably the best ones to know if she needs an epi-pen. An EMT would not see any hives and may not even think it is necessary but we know our daughter and her allergic history of reactions to various allergens.
Title: Re: Bendaryl vs. Epi ... help!
Post by: ajasfolks2 on October 01, 2014, 02:54:02 PM
Saw this quote on Facebook.  Supposedly attributable to Dr. Wallace from "recent" anaphylaxis conference.

Speaking about the role of antihistamines in anaphylaxis:

"Antihistamines are what you give to reduce itching and hives while you watch the patient die of anaphylaxis."

Title: Re: Bendaryl vs. Epi ... help!
Post by: CMdeux on October 01, 2014, 04:34:39 PM
{snort}



EXACTLY.

Title: Re: Bendaryl vs. Epi ... help!
Post by: LinksEtc on October 02, 2014, 08:39:12 PM
Tweeted by @AllergicLiving

"Allergist Talks About Anaphylaxis (Severe Allergic Reactions)"
https://m.youtube.com/watch?v=184oft9bW0s&feature=youtu.be

Quote
Antihistamines will never ever ever stop a severe anaphylaxis reaction from progressing. The right thing to do is, as early as possible with one of these episodes, is to use your epinephrine auto-injector


Title: Re: Bendaryl vs. Epi ... help!
Post by: Mfamom on October 02, 2014, 08:58:24 PM
Great Line