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Overall frequency of biphasic reactions was 7.36% of anaphylactic reactions with prospective studies reporting a frequency of 9.07%. Mean time to the second phase of BA was 8.13 hours (95% CI, 6.13-10.14) with similar times between both pediatric and adult populations.
Mean time = average time ?
Since many have a biphasic reaction within 2 hours.....that means many could be beyond 8 hours.