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Posted by LinksEtc
 - December 30, 2014, 08:14:00 AM
Tweeted by @AllergyEducator

"Food Allergens: Impacts and Challenges"
http://toolbox.foodproductdesign.com/Videos/2014/12/FTTb-Food-Allergens.aspx


Stephen L. Taylor, Ph.D.


------------------------------------


Tweeted by @eliza68

"How much is too much?: Threshold dose distributions for 5 food allergens"
http://www.jacionline.org/article/S0091-6749%2814%2901590-5/abstract





Posted by CMdeux
 - December 12, 2014, 10:43:41 AM
analysis of the available clinical data


What, and pretend that the stuff that IRB's won't approve just-- doesn't MATTER??

:insane: :dunce:


Sorry, but I have not got a lot of patience for this kind of thing.  That's just lousy science.

I mean-- does ANYONE truly think that designing a braking system in a car can just, I dunno...   ignore friction in doing calculations?  Because it's too hard to measure or something?

No?

Well, then, why is it okay to IGNORE the people who face the largest risks of death from cross-contamination when crafting policies to (nominally, clearly-- because it's far from pragmatically so) "protect" food allergic consumers.

I'm not buying it.  This is about protecting food manufacturers from liability, and giving them a pass on disclosure.  Nothing more.

Posted by LinksEtc
 - December 11, 2014, 11:06:17 AM
Tweeted by @AllergyEducator

Understanding food allergen thresholds requires careful analysis of the available clinical data

Steve L. Taylor, PhD, Geert F. Houben, PhD, Joseph L. Baumert, PhD, Rene R.W.R. Crevel, PhD, Katrina J. Allen, MD, PhD, Anthony E.J. Dubois, MD, Andre C. Knulst, MD, Benjamin C. Remington, PhD, Astrid G. Kruizinga, MSc, W. Marty Blom, PhD, Simon Brooke-Taylor, PhD
Published Online: November 21, 2014

-----


I can't seem to get access to this article, but my guess is that some of you will find it interesting.





Posted by LinksEtc
 - June 16, 2014, 08:57:02 PM
From FARE email:

QuoteMary Jane Marchisotto, senior vice president of research

QuoteMarchisotto and Laurie Harada, executive director of Anaphylaxis Canada, together with other advocates and researchers, are working on a paper examining patients' attitudes toward food allergen threshold labeling, which will be submitted for publication.


Reminds me to try & get to this thread soon ...
Docket FDA-2008-N-0429 - Advisory Labeling Comments & Info

Posted by LinksEtc
 - May 01, 2014, 11:20:14 PM
I am up too late tonight  :-/


"Precautionary labelling of foods for allergen content: are we ready for a global framework?"
http://www.waojournal.org/content/7/1/10

Tweeted by Aller_MD
Posted by rebekahc
 - March 13, 2014, 10:27:14 AM
Or, to piggyback on SpaceCanada's example...  What if I get all the contaminated pieces of cereal (or whatever) in my one serving?  How do they determine the level of contamination per serving?  There's X mg of contamination per batch, a batch = Y servings therefore there's Z mg contamination per serving? That may work mathematically, but that's not the way contamination works.  One peanut per batch is very low contamination per serving but I'd hate to get the serving that actually has the peanut.  I'm thinking the food industry will treat contamination the same way they do trans-fat (manipulating the math to say there's 0g trans-fat when that's not really true -especially if you eat more than one serving).
Posted by spacecanada
 - March 13, 2014, 09:42:35 AM
Great finds, Links! Nowhere, though, does it mention what would happen if a sensitive individual ate multiple servings of a product containing 0.1 mg of peanut, pushing that dose up to 1+ mg, which could cause a reaction.  Someone eating a whole box of cereal in a day, for instance, or half a box of cookies.  (I'm guilty of both!)  Or simply various foods throughout the day that may have 0.1 mg in them, but combined over the day create a much higher dose?  Why is this simple real world situation being ignored?
Posted by LinksEtc
 - March 13, 2014, 09:03:17 AM
http://ohmahdeehness.wordpress.com/2014/03/12/shared-equipment-facilities-and-food-allergy/

QuoteThis month's Food Allergy Buzz Blog Carnival theme is cross contamination

QuoteSomewhere between a company deciding whether a trace amount is too small to disclose (see above) or a company that makes a blanket warning on a single ingredient item (see above also), I think there needs to be a real discussion about labeling and disclosure not just for the benefit of food allergic families but all who wish to know what they're eating.


Posted by LinksEtc
 - August 23, 2013, 04:28:19 PM
An older related thread:

http://allergy.hyperboards.com/action/view_topic/topic_id/17461

----------------------------------

http://allergicliving.com/index.php/2013/12/30/is-peanut-oil-safe-or-not/
QuoteIf your allergist is comfortable with you consuming refined peanut oil, then you will need to take great care to ensure that you use only products with this type of oil. This will likely involve contacting a manufacturer or restaurant chain, and checking each time.

----------------------------------

Food Allergy Research & Resource Program, University of Nebraska
FDA-2012-N-0711-0053
Quote
In the passage of FALCPA, Congress wisely exempted highly refined oils likely because of good evidence that highly refined peanut and soybean oils were safe for ingestion by peanut- and soybean-allergic individuals (Hourihane et al., 1997; Bush et al., 1985). Highly refined oils contain virtually no detectable protein with the protein being largely removed by the refining process (Rigby et al., 2011).

----------------------------------

Peanut Threshold Study

Posted by twinturbo
 - June 03, 2013, 07:59:02 AM
Apple as an allergen is almost always associated with birch sensitivity, which while not a food allergen is a major or common environmental allergen, and even with environmental allergy immunotherapy there is a risk for anaphylaxis as most places won't deliver the interval 'shots' without the patient bringing their EAI with them in conjunction to a 30 min office wait post-injection.

Whereas peanut, milk, etc tend to be primary stand alone allergens fruits seem to start with common pollen allergens. Janelle and I happen to be a couple of outliers that anaphylax and even then there's a couple standard deviations between my reactions and Janelle's. Our birch sensitization may be similar, however.

But yeah, highlight and underscore everything CM wrote better than I could about when papers become unread, unquestioned, misinterpreted absolute truth.
Posted by CMdeux
 - June 02, 2013, 09:13:29 PM
I doubt it, too.  The very very few studies that exist on 'how little is enough' suggest that some allergens have thresholds that are really, really, really low for some individuals...

but the N's are so small in those studies that it could quite easily be true that they only capture the central two standard deviations, and not the actual tails of the sensitivity distribution.  The ones that I'm familiar with that use good experimental design tend to report that some individuals report subjective symptoms from the lowest doses in the range.

Clinicians know that these people exist.  They know because they see them.  Not every outlier gets a write-up in a medical journal, because their doctors are busy being-- well, clinicians.

Besides, the extant studies do NOT include many common allergens that are-- just anecdotally-- thought to not be life-threatening at trace levels-- things like soy, wheat, and non-seed allergens outside of the top 8.  Obviously they ARE life-threatening for some people, as you do occasionally hear reports of fatalities, particularly outside the top 8.  One of the saddest allergy fatality tales I've ever heard is of the young mum in the UK who died after opening a can of tomatoes in order to make her children a meal.  SHE clearly had a pretty low threshold-- and was possibly taken by surprise by just how low?-- and to an allergen that "shouldn't" be possible.

Posted by Janelle205
 - June 02, 2013, 08:52:50 PM
Quote from: CMdeux on June 02, 2013, 08:07:29 PM
Are only some allergens special that way?

Like I said-- we. don't. know.

I doubt it.  Apples are on almost every 'least allergenic foods' list out there.  And I react to them in ways that really do not seem possible, except that it has happened, so it has to be.
Posted by CMdeux
 - June 02, 2013, 08:07:29 PM
The reason that throwing THAT population of food allergic people under the bus makes me so mad?

(Aside from the fact that my DD is probably in that group with peanut, anyway.)

Because they are the group that already faces the greatest limitation and risk in their daily lives.  Nothing like having their own patient advocacy group and government tell them "you're outliers.  Your safety doesn't matter."

How many of those people is it okay to give the giant kiss-off to, anyway?

Are only some allergens special that way?

Like I said-- we. don't. know.

As long as we don't know the answer to that question, this strikes me as being much like the treatment that sesame allergy has gotten by the FDA.  If they don't have the data, then it must not be important, right?  :-/

 
Posted by Janelle205
 - June 02, 2013, 04:41:42 PM
I took benadryl and pain killers, so I'm worried that this is going to seem mangled, but I'm trying.

Going along with what CM said:

I know that I am a statistical outlier.  My doctor and I laughed yesterday when he said "What is it like to be you?"

Not only does threshold level and reaction severity not necessarily correlate among the population, it also doesn't necessarily correlate within a person.

I have had severe reactions to tiny amounts of one allergen - anaphylaxis from what we assume was contact ingestion.  I have also had severe reactions to a different allergen which I directly ingested a lot more before I started reacting.


I'm not sure what that means for the population overall, but I just wanted to share.  I can have skin exposure to a small amount of very processed apple and have a serious reaction.  I could probably eat a pan of scrambled eggs and just end up with a few hives, eczema, and a stomach ache.  (Ok, I might throw up, but that is probably more because I think that eggs are gross.)