Food Allergy Support

Specific Food Allergies => Seed Allergy => Topic started by: AdminCM on August 22, 2011, 02:30:37 PM

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Title: Sesame Research (links clearinghouse thread)
Post by: AdminCM on August 22, 2011, 02:30:37 PM
Sesame Research
Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:32:22 PM
LinksEtc
Member
Posted: 11.19.2010 at 01:45:16


I know we have a general news & research area, but I thought it might be nice to start a research thread specifically for sesame.

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"Characterizing the relationship between sesame, coconut, and nut allergy in children"
http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3038.2010.00997.x/full

published online: 15 NOV 2010

Quote
Sensitization to sesame was more likely in children with positive SPT to peanuts (odds ratio [OR] = 6.7, 95% confidence interval [CI] [2.7–16.8], p < 0.001) and tree nuts (OR = 10.5, 95% CI [4.0–27.7], p < 0.001). Children with histories of both peanut and tree nut reaction were more likely to have a history of sesame reaction (OR = 10.2, 95% CI [2.7–38.7], p < 0.001).


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"Sesame and nut allergies may often strike together"
http://wtaq.com/news/articles/2011/jan/13/sesame-and-nut-allergies-may-often-strike-together/#

Quote
Dr. Wanda Phipatanakul, of Children's Hospital Boston, and her colleagues studied the medical records of 191 children


Quote
Between 13 percent and 15 percent of peanut and tree nut allergic children were actually allergic to sesame


Quote
The rate of sesame allergy jumped up to 50 percent for children allergic to both nuts


« Last Edited by LinksEtc 01.14.2011 at 10:04:03 »


Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:33:37 PM
LinksEtc
Member
Posted: 11.19.2010 at 01:59:54
 

"Winchester Hospital Allergist Vandana Krishna, MD Highlights Need for Education on Sesame Allergy"
http://www.winchesterhospital.org/community/SitePages/NewDetails.asp?NewsID=7B84B8AB6F714AC1AFDD10A9B7237235

Quote
she recommends education specific to sesame should be provided to primary care physicians, parents and day care and school personnel. She also advocates for the food industry being subjected to stricter labeling guidelines on this emerging food allergen.


« Last Edited by LinksEtc 11.19.2010 at 02:02:53 »


Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:34:55 PM
LinksEtc
Member
Posted: 01.17.2011 at 08:39:25
 

Nice article ...

"The Allergens to Watch – Sesame to Lentils and More"
http://allergicliving.com/index.php/2010/08/30/the-allergens-to-watch/

Quote
Wood adds that sesame is a raw oil, and as a result can be just as allergenic as the seeds themselves.


In the USA, sesame 
Quote
can still be hidden as “tahini”, “spices” or “natural flavouring”.


In Canada, the
Quote
government agency not only looks at which allergens are the most common, but which ones are mostly likely to produce the most severe reactions



Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:41:58 PM
hk
Member
Posted: 01.18.2011 at 12:46:40


Great thread. Thanks for starting this.


7 yo DD - TN, PN, egg, sesame, avocado, flax, fish, cherry, mango
Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:42:47 PM
LinksEtc
Member
Posted: 01.18.2011 at 08:02:00


Thanks hk!


Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:47:44 PM
Yve
Member
Posted: 01.31.2011 at 09:54:49


Thanks for these resources.


Baby girl: Dairy, soy, fish, seeds, eggs, tree and peanuts
Big Girl: Dairy, eggs and nuts
Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:49:25 PM
LinksEtc
Member
Posted: 03.10.2011 at 11:11:31
 

01.31.2011 at 09:54:49, Yve wrote:
Quote
Thanks for these resources.


You're welcome Yve!

-------------------------------------------------

"Allergy to Seeds"

Ilan Dalal

Pediatric Allergy and Immunology
Volume 22, Issue 1pt2, pages e150–e154, February 2011

http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3038.2010.00985.x/abstract

Quote
have progressed from 'anecdotal' to a serious worldwide health problem



Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 02:50:26 PM
LinksEtc
Member
Posted: 05.19.2011 at 07:50:26
 

"Food Allergy: Is Sesame Seed the “Middle Eastern Peanut"?"
http://allergynotes.blogspot.com/2011/05/food-allergy-is-sesame-seed-middle.html

Quote
Although specific IgE to peanut were higher than for sesame, peanut-induced allergic reactions were mild, in contrary to sesame where anaphylaxis was the only clinical manifestation.


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http://journals.lww.com/waojournal/Abstract/2011/01000/Food_Allergy_in_Lebanon__Is_Sesame_Seed_the.1.aspx

Quote
Recently, sesame has been recognized as an increasingly frequent and potentially severe allergen.



Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 03:00:41 PM
CMdeux
Moderator1
Posted: 05.31.2011 at 01:49:38


Thank you so much for this!! We should definitely create a linker thread from the research forum to this thread, but I think it is a terrific idea to house individual allergen research like this.
 
So much of the clinical research is becoming allergen-specific. It's really a wealth of information, and I'm so encouraged that the nuances between food allergens are being explored (for example, the conventional wisdom re: which allergen proteins are the "important" ones in egg, milk, and peanut allergy) but it sure makes it a lot denser in this forest.  :thumbsup:

Parsing it out like this is very helpful to let us see the individual grove that we happen to be standing in, as we look at all these trees. THANK YOU!!


"To travel hopefully is a better thing than to arrive." -Robert Louis Stevenson

USA

Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 03:01:41 PM
LinksEtc
Member
Posted: 06.01.2011 at 09:24:00


Thanks CM!


Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 03:03:13 PM
LinksEtc
Member
Posted: 07.13.2011 at 06:39:20
 

"Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants"

The Journal of Allergy and Clinical Immunology
Volume 127, Issue 3 , Pages 668-676.e2, March 2011

www.jacionline.org/article/S0091-6749(11)00135-7/abstract

Quote
Recruitment occurred at childhood immunization sessions in Melbourne, Australia.


Quote
Amongst 2848 infants (73% participation rate), the prevalence of any sensitization to peanut was 8.9% (95% CI, 7.9-10.0); raw egg white, 16.5% (95% CI, 15.1-17.9); sesame, 2.5% (95% CI, 2.0-3.1); cow's milk, 5.6% (95% CI, 3.2-8.0); and shellfish, 0.9% (95% CI, 0.6-1.5). The prevalence of challenge-proven peanut allergy was 3.0% (95% CI, 2.4-3.8); raw egg allergy, 8.9% (95% CI, 7.8-10.0); and sesame allergy, 0.8% (95% CI, 0.5-1.1).


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The link isn't working again, but you can copy and paste the entire link.

« Last Edited by LinksEtc 07.14.2011 at 10:05:30 »


Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 03:04:12 PM
LinksEtc
Member
Posted: 07.13.2011 at 07:07:08
 

"Skin Prick Test Wheal Size Thresholds Identified"

22-Apr-11
 
Elsevier Global Medical News
 
BY SHERRY BOSCHERT

http://www.medconnect.com.sg/tabid/92/s5/Allergy-Immunology/ct1/c40916/Skin-Prick-Test-Wheal-Size-Thresholds-Identified-/Default.aspx

Quote
A 9-mm wheal after skin prick testing provided a 95% positive predictive value for egg or peanut allergy in an analysis of data from 5,000 12-month-old infants


Quote
71 with sesame challenges. None of the wheal sizes after sesame challenges reached a 95% positive predictive value for allergy, said Dr. Gurrin of the University of Melbourne.



Title: Re: Sesame Research (links clearinghouse thread)
Post by: admin rebekahc on September 09, 2011, 03:05:38 PM
LinksEtc
Member
Posted: 09.08.2011 at 11:29:09
 

I know this is a more general research article, but I wanted to keep track that sesame was a common allergen that was being challenged.

Outpatient open oral food challenges – feasible and “feed-able”
http://www.aaaai.org/global/latest-research-summaries/Current-JACI-Research/outpatient-open-oral-food-challenges-feasible-an.aspx

Quote
reviewed 22 months worth of successive open OFCs performed at a university-based pediatric allergy outpatient clinic (Mount Sinai School of Medicine, New York, NY)



Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on March 23, 2012, 08:10:28 AM
"Food Allergy in Kids Not Being Optimally Diagnosed"
http://www.medscape.com/viewarticle/753505

Quote
The survey involved 40,104 children; of these, investigators identified 3339 children with food allergy.


Quote
oral food challenge was done in just 15.6% of children


Quote
Formal diagnoses were most frequently confirmed by oral food challenge for milk allergy (22.4%), soy (19.2%), peanut (16.1%), wheat (15.5%), shellfish (14.4%), tree nut (12.6%), egg (12.4%), sesame (11.2%), and fin fish (9.1%).
Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on March 23, 2012, 03:48:57 PM
"Demographic Predictors of Peanut, Tree Nut, Fish, Shellfish, and Sesame Allergy in Canada"

M. Ben-Shoshan,1 D.W. Harrington,2 L. Soller,3 J. Fragapane,3 L. Joseph,3, 4
Y. St. Pierre,3 S. B. Godefroy,5 S. J. Elliott,6 and A. E. Clarke3, 7

http://www.medicine.mcgill.ca/epidemiology/joseph/publications/Medical/benshoshan2012.pdf
Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on March 23, 2012, 04:09:54 PM
"Sesame Allergy: Role of Specific IgE and Skin Prick Testing in Predicting Food Challenge Results"

Perdita Permaul, MD,ab Lisa M. Stutius, MD,ab William J. Sheehan, MD,ab Pitud Rangsithienchai, MD, MA,ac Jolan E. Walter, MD, PhD,ab Frank J. Twarog, MD, PhD,ab Michael C. Young, MD,ab Jordan E. Scott, MD,ab Lynda C. Schneider, MD,ab and Wanda Phipatanakul, MD, MSab

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131114/

Quote
Although our study is limited by a small sample of cases, there is an inclination for predicting the outcome of a sesame food challenge with SPT based on our results



Quote
Notably, 29% of sesame allergic patients had a sesame-specific IgE < 0.35 kUA/L. This is in contrast to the findings of Zavalkoff et al. who reported a cut-off < 0.35 kUA/L as being useful in excluding a diagnosis of sesame allergy.
Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on April 11, 2012, 05:25:34 PM
This is from 2003 ... I'm not sure if there has been more research since then.  Not a big sample size for sesame.


"Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenges."

http://www.ncbi.nlm.nih.gov/pubmed/12911777

Quote
Data from 125 positive oral challenges to egg, 103 to peanut, 59 to milk and 12 to sesame seeds were analysed. Haemodynamic modifications were observed in 2%, 3%, 1.7%, and 8% of the oral challenges (OCs) to egg, peanut, milk and sesame, respectively. Respiratory symptoms were observed in 12%, 20%, 10% and 42% of egg, peanut milk and sesame allergies, respectively. A cumulative reactive dose inferior or equal to 65 mg of solid food or 0.8 mL of milk characterized 16%, 18%, 5% and 8% of egg, peanut, milk and sesame allergies, respectively. 0.8% of egg allergies, 3.9% of peanut allergies, and 1.7% of milk allergies reacted to 10 mg or less of solid food or to 0.1 mL for milk. The lowest reactive threshold has been observed at less than 2 mg of egg; 5 mg of peanut, 0.1 mL of milk and 30 mg of sesame seed. Ten out of 29 OC with peanut oil, two out of two OC with soy oil and three out of six OC with sunflower oil were positive. Five out six OC with sesame oil were positive: 1 and 5 mL induced an anaphylactic shock.
Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on April 11, 2012, 05:27:52 PM
"Sesame allergy: a growing food allergy of global proportions?"
http://www.ncbi.nlm.nih.gov/pubmed/16095135

Quote
Evidence was found for increased reporting of sesame allergy during the past 5 decades, with reports mostly from developed countries. Clinically, most sesame allergy was presented in at least 2 major forms: (1) immediate hypersensitivity, often expressed as systemic anaphylaxis, associated with positive skin prick test and/or IgE antibody test results to sesame proteins with some cross-reactivity with other foods, and (2) delayed hypersensitivity to lignin-like compounds in sesame oil clinically expressed as contact allergic dermatitis. There were a few cases of immediate hypersensitivity to sesame with negative skin prick test and/or IgE antibody test results that were confirmed by oral challenge tests.
Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on April 11, 2012, 05:29:37 PM
Is there a positive predictive value for sesame?

Sesame prevalence studies: Canada & USA
Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on October 06, 2013, 08:19:03 PM
"Oleosines in sesame allergy"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723685/
Quote
Oleosins have been described by others [2], and are important allergens from sesame seed. Since they are hydrophobic, they are not present at commercial extracts or extract prepared from sesame seed in saline, or the CAP system extract.
Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on October 24, 2013, 07:43:37 PM
sesame seed study.

"Clinical Characteristics Of - And Predictive Diagnostic Factors For - Sesame Seed Allergy In
Food-Allergic Children"

Quote
a significant proportion of sesame-seed-allergic children were able to tolerate low amounts of sesame ingestion. This seems to be a common clinical finding in sesame allergy, perhaps reflecting peculiarities of sesame allergens and digestive processing thereof.


Quote
tolerance of loose seeds does not always confirm tolerance of sesame concentrates




Just a reminder .... sesame-allergic people should strictly avoid all sesame, including cross-contamination, unless their allergist tells them otherwise.


Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on April 21, 2014, 02:36:47 PM
sesame allergy patient study uk


"Sesame allergy in Britain: a questionnaire survey of members of the Anaphylaxis Campaign."
http://www.ncbi.nlm.nih.gov/pubmed/15787876
Quote
Sesame should be identified clearly as an ingredient and separately from nuts and peanuts when it may be an allergen contaminant. People at potential risk need clear allergy diagnosis and informed guidance to enable them to avoid this key allergen more easily.



Title: Re: Sesame Research (links clearinghouse thread)
Post by: LinksEtc on March 28, 2015, 03:55:25 PM
Tweeted by @AllergyEducator


"Cross reactivity of seed allergens"
http://www.aaaai.org/ask-the-expert/cross-reactivity-seed.aspx?utm_content=buffer77698&utm_medium=social&utm_source=linkedin.com&utm_campaign=buffer

Quote
I think your summary of the literature suggesting that we do not have a great deal of detail on the cross reactivity of ingested seeds is a fair assessment. The 2S, 7S, 11S storage proteins are common to many seeds and could provide cross reactivity. However, the clinical evidence of the importance of this cross-reactivity is not well substantiated.