Eosinophilic Esophagitis(EE) (http://allergy.hyperboards.com/action/view_topic/topic_id/2629/start/1)
(even though this thread has been extensively edited-- including many post-deletions-- at this point, it is still FILLED with really good information, especially in the first few pages)
"Can patients with cow's milk-mediated eosinophilic esophagitis tolerate baked milk?"
http://www.aaaai.org/global/latest-research-summaries/Current-JACI-Research/milk-eosinophilic-esophagitis.aspx (http://www.aaaai.org/global/latest-research-summaries/Current-JACI-Research/milk-eosinophilic-esophagitis.aspx)
Quotecow's milk mediated EoE (CMME)
QuoteThe authors' findings suggest that a majority of patients with CMME could tolerate baked milk products without recurrence of EoE.
http://allergynotes.blogspot.com/2014/01/eosinophilic-esophagitis-eoe-top.html (http://allergynotes.blogspot.com/2014/01/eosinophilic-esophagitis-eoe-top.html)
Eosinophilic Esophagitis—Explaining a "New" Disease
http://www.asthmaallergieschildren.com/2014/01/19/eosinophilic-esophagitis-explaining-a-new-disease/ (http://www.asthmaallergieschildren.com/2014/01/19/eosinophilic-esophagitis-explaining-a-new-disease/)
A few other board EE threads:
Just diagnosed with Eosinophilic Esophagitis! (http://foodallergysupport.olicentral.com/index.php/topic,7596.0.html)
EE elecare support (http://foodallergysupport.olicentral.com/index.php/topic,7294.0.html)
Confusion about EE (http://foodallergysupport.olicentral.com/index.php/topic,258.0.html)
Eosinophilic gastroenteritis: Neocate & insurance (http://foodallergysupport.olicentral.com/index.php/topic,251.0.html)
EE diagnosis process (http://foodallergysupport.olicentral.com/index.php/topic,250.0.html)
EE Videos (http://foodallergysupport.olicentral.com/index.php/topic,244.0.html)
Rotation Diets for MFA / Eosinophilic Disorders (http://foodallergysupport.olicentral.com/index.php/topic,237.0.html)
EE (http://foodallergysupport.olicentral.com/index.php/topic,221.0.html)
http://www.kidswithfoodallergies.org/resourcetopic.php?topic=gastrointestinal-disorders (http://www.kidswithfoodallergies.org/resourcetopic.php?topic=gastrointestinal-disorders)
http://community.kidswithfoodallergies.org/forum/eosinophilic_disorders (http://community.kidswithfoodallergies.org/forum/eosinophilic_disorders)
http://apfed.org/drupal/drupal/index.php (http://apfed.org/drupal/drupal/index.php)
http://www.cincinnatichildrens.org/health/e/eosinophilic-esophagitis-ee/ (http://www.cincinnatichildrens.org/health/e/eosinophilic-esophagitis-ee/)
http://www.cincinnatichildrens.org/patients/care/stories/patient-stories/ee/default/ (http://www.cincinnatichildrens.org/patients/care/stories/patient-stories/ee/default/)
http://www.medicinenet.com/eosinophilic_esophagitis/article.htm (http://www.medicinenet.com/eosinophilic_esophagitis/article.htm)
http://allergies.about.com/od/foodallergies/a/ee.htm (http://allergies.about.com/od/foodallergies/a/ee.htm)
http://www.nationaljewish.org/healthinfo/conditions/eosinophilic-esophagitis/ (http://www.nationaljewish.org/healthinfo/conditions/eosinophilic-esophagitis/)
http://www.hopkinschildrens.org/Eosinophilic-Esophagitis.aspx (http://www.hopkinschildrens.org/Eosinophilic-Esophagitis.aspx)
http://www.chop.edu/service/allergy/allergy-and-asthma-information/eosinophilic-esophagitis.html (http://www.chop.edu/service/allergy/allergy-and-asthma-information/eosinophilic-esophagitis.html)
http://www.aaaai.org/conditions-and-treatments/related-conditions/eosinophilic-esophagitis.aspx (http://www.aaaai.org/conditions-and-treatments/related-conditions/eosinophilic-esophagitis.aspx)
"As one food allergy resolves, another may develop"
http://www.eurekalert.org/pub_releases/2014-03/chop-aof022814.php (http://www.eurekalert.org/pub_releases/2014-03/chop-aof022814.php)
QuoteThe researchers performed a retrospective analysis of all children seen at CHOP for EoE between 2000 and 2012, a total of 1,375 patients. Of that number, 425 could be shown to have a definite food causing their condition—most commonly milk, egg, soy and wheat. Within that subgroup, 17 patients had developed EoE to a food after having outgrown IgE-mediated allergy to that specific food.
"Pediatric Eosinophilic Esophagitis: A 10-Year Experience At a Canadian Tertiary Care Centre"
Jason A. Ohayon, MD, Perri R. Tutelman, Jefferson Terry, MD, PhD, Mary E. Sherlock, MB BCh, BAO, PhD
https://aaaai.confex.com/aaaai/2014/webprogram/Paper11128.html (https://aaaai.confex.com/aaaai/2014/webprogram/Paper11128.html)
QuoteApproximately half of the patients treated with corticosteroids reported symptomatic improvement while over three-quarters of patients reported an improvement on allergy avoidance dietary therapy. At a median follow-up of 31.1 (IQR=81.8-13.4) months, 16 (17%) patients had no change in symptoms from diagnosis, 53 (56%) patients continued to experience symptoms but at a decreased severity, and 17 (18%) experienced a complete resolution of symptoms. Eight (9%) of patients were lost to follow up.
"Clinical Characteristics Of Eosinophilic Esophagitis - a Case Series Of 30 Patients"
Susana D. Piedade, Diana Silva, Bruno Simões, Ângela Gaspar, Sandra Morgado, Filipa Santos, Mário Morais-Almeida
https://aaaai.confex.com/aaaai/2014/webprogram/Paper12477.html (https://aaaai.confex.com/aaaai/2014/webprogram/Paper12477.html)
QuoteThe most commonly reported symptoms were food impaction (67%), dysphagia (53%), abdominal pain (40%), vomits (37%) and heartburn (37%); the first 2 were significantly more frequent in adults and adolescents. Children's (≤12 years) main complaint was vomits (60%) and failure to thrive occurred in 2 cases. Most had personal history of allergic disease (87%) and aeroallergens sensitization (71%).
"Patient Ratings Of Various Eosinophilic Esophagitis Treatment Options"
Samantha K. Lin, MD, Neelu Kalra, MD, Gisoo Ghaffari, MD FAAAAI
https://aaaai.confex.com/aaaai/2014/webprogram/Paper11676.html (https://aaaai.confex.com/aaaai/2014/webprogram/Paper11676.html)
QuoteRationale: Eosinophilic esophagitis (EoE) can be treated with various combinations of a proton pump inhibitor (PPI), topical steroid (TS), and elimination diet (D). This study assessed which treatments patients were using and sought to determine patient/caregiver ratings of EoE symptoms, response to treatment, and tolerability of therapy.
QuoteUse of a topical steroid was associated with significantly higher treatment response ratings and very few side effects.
"New EoE Test Developed"
http://allergicliving.com/2013/12/05/new-eoe-test-developed/ (http://allergicliving.com/2013/12/05/new-eoe-test-developed/)
QuoteResearchers at the Cincinnati Children's Hospital have developed a ground breaking diagnostic test for eosinophilic esophagitis, or EoE.
QuoteIt also differentiated between those whose EoE was in remission and those who didn't have EoE at all.
QuoteThe test uses a method known as gene expression profiling
Tweeted by @AllergieVoeding
"Management Guidelines of Eosinophilic Esophagitis in Childhood"
http://mobile.journals.lww.com/jpgn/_layouts/oaks.journals.mobile/articleviewer.aspx?year=2014&issue=01000&article=00027 (http://mobile.journals.lww.com/jpgn/_layouts/oaks.journals.mobile/articleviewer.aspx?year=2014&issue=01000&article=00027)
QuoteThis position paper of the Eosinophilic Esophagitis Working Group (see Appendix) and the Gastroenterology Committee of ESPGHAN aims at providing practical guidelines for the management of children and adolescents with EoE, based on available evidence where possible. If sufficient evidence is lacking, our recommendations are based on expert opinion and personal practice.
Tweeted by @AllergyKidsDoc
"ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE)"
http://www.nature.com/ajg/journal/v108/n5/full/ajg201371a.html (http://www.nature.com/ajg/journal/v108/n5/full/ajg201371a.html)
Am J Gastroenterol 2013; 108:679–692; doi:10.1038/ajg.2013.71; published online 9 April 2013
QuoteEsophageal eosinophilia and eosinophilic esophagitis (EoE) are increasingly recognized and prevalent conditions, which now represent common clinical problems encountered by gastroenterologists, pathologists, and allergists.
QuoteIn this evidence-based review, recommendations developed by adult and pediatric gastroenterologists are provided for the evaluation and management of these patients.
Tweeted by @AllergyNet
"Elimination diets in the management of eosinophilic esophagitis"
http://www.dovepress.com/elimination-diets-in-the-management-of-eosinophilic-esophagitis-peer-reviewed-article-JAA (http://www.dovepress.com/elimination-diets-in-the-management-of-eosinophilic-esophagitis-peer-reviewed-article-JAA)
QuoteThis paper reviews the evidence for all types of dietary therapy in eosinophilic esophagitis.
http://blog.foodallergy.org/2014/07/14/researchers-discover-cause-of-eosinophilic-esophagitis/ (http://blog.foodallergy.org/2014/07/14/researchers-discover-cause-of-eosinophilic-esophagitis/)
Tweeted by @DrVes
"Swallowed topical corticosteroids reduce the risk for long-lasting bolus impactions in eosinophilic esophagitis"
http://onlinelibrary.wiley.com/doi/10.1111/all.12455/abstract?utm_content=buffer98edb&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer (http://onlinelibrary.wiley.com/doi/10.1111/all.12455/abstract?utm_content=buffer98edb&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer)
Tweeted by @xFoodAllrgyhelp
"Study Finds Cause of Mysterious Food Allergy, Suggests New Treatment Strategy"
http://www.cincinnatichildrens.org/news/release/2014/eosinophilic-esophagitis-treatment/ (http://www.cincinnatichildrens.org/news/release/2014/eosinophilic-esophagitis-treatment/)
Quote"In a nutshell, we have used cutting edge genomic analysis of patient DNA as well as gene and protein analysis to explain why people develop EoE," Rothenberg explained. "This is a major breakthrough for this condition and gives us a new way to develop therapeutic strategies by modifying the expression of calpain14 and its activity.
Tweeted by @FdAllergySleuth
High-Dose Fluticasone Effective Against Eosinophilic Esophagitis
NIH-Funded Study Also Uncovers Evidence of Steroid-Resistant Disease
http://www.niaid.nih.gov/news/newsreleases/2014/Pages/fluticasoneEoE.aspx (http://www.niaid.nih.gov/news/newsreleases/2014/Pages/fluticasoneEoE.aspx)
"Eosinophilic Esophagitis - Scientific Excitement - Part 1 of 2"
http://foodallergysleuth.blogspot.com/2014/07/eosinophilic-esophagitis-scientific.html (http://foodallergysleuth.blogspot.com/2014/07/eosinophilic-esophagitis-scientific.html)
QuoteThe allergy world was abuzz this past week that a major research breakthrough for Eosinophilic Esophagitis (EoE) was published in Nature Genetics (1), spear-headed by Dr. Marc Rothenberg's lab at Cincinnati Children's Hospital. For anyone dealing with this devastating allergic disorder, the news was welcome, but what does it all mean?
--------------------------------------
"Eosinophilic Esophagitis - Scientific Excitement - Part 2 of 2"
http://foodallergysleuth.blogspot.com/2014/08/eosinophilic-esophagitis-scientific.html (http://foodallergysleuth.blogspot.com/2014/08/eosinophilic-esophagitis-scientific.html)
QuoteMany factors contribute to the complex interplay of nature (DNA) and nurture (environmental effects on DNA expression) in both health and disease, and this is true for EoE and other allergic disorders.
QuoteCAPN14 is clearly one piece of the complex machinery that scientists are trying to reverse engineer.
"Figuring out what was preventing Hunter Gallagher from swallowing would have taken a lot longer, if not for an ingenious device — a sponge on a string."
http://www.everydayhealth.com/news/eating-anything-made-him-sick/?xid=tw_dsg (http://www.everydayhealth.com/news/eating-anything-made-him-sick/?xid=tw_dsg)
QuoteBut Hunter's doctors at the Mayo Clinic had another idea: a simple sponge on a string developed in the United Kingdom.
Quote
When a doctor pulls it back up, it scrapes the lining of the esophagus. It takes just five minutes and a pilot study found it was just as effective as an endoscopy.
Eosinophils and IL-9 promote mast cell accumulation in pediatric eosinophilic esophagitis
...
This study has a number of potentially important clinical implications. It demonstrates the eosinophil is an integral piece of the inflammatory puzzle in EoE and that by specifically removing the eosinophil using an anti-IL-5 antibody, there are secondary effects on other cells such as mast cells. In addition, this study shows, for the first time, that IL-9 is present and likely to be important in the pathogenesis of EoE. As such, IL-9 may provide a new therapeutic target in EoE.
The Journal of Allergy and Clinical Immunology (JACI) is the official scientific journal of the AAAAI and is the most cited journal in the field of allergy and clinical immunology
http://www.aaaai.org/global/latest-research-summaries/Current-JACI-Research/eosinophils-Il-9-promote-mast-cell.aspx (http://www.aaaai.org/global/latest-research-summaries/Current-JACI-Research/eosinophils-Il-9-promote-mast-cell.aspx)
"Scientists identify potential marker of EoE disease activity"
http://tinyurl.com/hxmqhqn (http://tinyurl.com/hxmqhqn)
QuoteA potential marker of disease activity for a severe and often painful food allergic disease called eosinophilic esophagitis (EoE) has been discovered by researchers, possibly sparing children with EoE the discomfort and risk of endoscopic procedures to assess whether their disease is active.
QuotePublished May 16 in the Journal of Allergy and Clinical Immunology, researchers at the Cincinnati Center for Eosinophilic Disorders (CCED) at Cincinnati Children's Hospital Medical Center led the study.
----------------------
Tweeted by @AllergyEducator
"Food Allergy Testing in Eosinophilic Esophagitis"
http://tinyurl.com/l3ynyzn (http://tinyurl.com/l3ynyzn)
Tweeted by @Aller_MD
"CHOP joins CEGIR to advance treatment of eosinophilic disorders"
http://www.news-medical.net/news/20141009/CHOP-joins-CEGIR-to-advance-treatment-of-eosinophilic-disorders.aspx?utm_content=buffercf412&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer (http://www.news-medical.net/news/20141009/CHOP-joins-CEGIR-to-advance-treatment-of-eosinophilic-disorders.aspx?utm_content=buffercf412&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer)
QuoteA five-year, $6.25 million NIH grant will establish the Consortium of Eosinophilic Gastrointestinal Disease Researchers, or CEGIR.
I saw on twitter.
"Boy who couldn't eat now can stomach 12 foods"
http://www.wotimes.com/2015/01/boy-couldnt-eat-now-can-stomach-12-foods/ (http://www.wotimes.com/2015/01/boy-couldnt-eat-now-can-stomach-12-foods/)
:paddle: for me - always.read.fully - had to undo my rt.
At first I thought this was just a nice EE article, but now I'm concerned about some of the info in it (although I am glad the boy is doing better).
Quotethe Hargers visited the Gerson Institute in San Diego
QuoteThe alternative dietary Gerson Therapy was developed by Max Gerson (1881-1959), a German-born American physician who originally came up with the idea as a cure for his debilitating migraines. He further claimed it was a cure for cancer and most chronic, degenerative diseases.
----------------------------------
Reminded me of this :-[ .....
Tweeted by @ScienceBasedMed
"A tale of two unnecessarily doomed aboriginal girls with leukemia"
January 20, 2015
http://scienceblogs.com/insolence/2015/01/20/a-tale-of-two-unnecessarily-doomed-aboriginal-girls-with-lymphoblastic-leukemia/ (http://scienceblogs.com/insolence/2015/01/20/a-tale-of-two-unnecessarily-doomed-aboriginal-girls-with-lymphoblastic-leukemia/)
QuoteBrian Clement's clinic has nothing to do with Ongwehowe Onongwatri:yo (indigenous medicines) and everything to do with good, old-fashioned European-American quackery focused mainly on wheatgrass, raw vegan diet, and "detoxification."
Quotethere is still another aboriginal girl with lymphoblastic leukemia who has abandoned chemotherapy, with the blessing of her tribal chiefs and family, in favor of the quackery peddled by a Yankee in Florida. We don't know her name due to privacy concerns enforced during her court case but we do have an update about her condition to juxtapose with the death of Makayla Sault.
--------
Here's more ...
"The (Not-So-)Beautiful (Un)Truth about the Gerson protocol and cancer quackery"
http://www.sciencebasedmedicine.org/the-not-so-beautiful-untruth-about-the-gerson-therapy-and-cancer-quackery/ (http://www.sciencebasedmedicine.org/the-not-so-beautiful-untruth-about-the-gerson-therapy-and-cancer-quackery/)
That's a lot to go through. But....yes....he scoped clean and that's so, so wonderful. :heart: