As someone who has had Lyme disease, I use DEET exclusively for bug purposes in the summers when I work at a camp. I use the 100% deet, which comes in a small bottle, but that is more because the other kinds generally have some sort of scent that makes me wheeze.
I almost always wear long pants and spray mostly on the clothes. I wear a mask when I put the spray on so that I don't inhale any of it. And I always shower it off before bed. When I was a counselor and went camping, I would leave the bug spray on until I was ready to go to the tent for the night, then wipe quickly with wipes, bag the wipes up and hang (bear country) and then get into the tent for the night.